-transparent.png){kind=logo}
Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase. 2010
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
Institute of Organic Chemistry and Biochemistry, Academy of Sciences vvi, Flemingovo 2, 166 10 Prague 6, Czech Republic.
Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase (TP, EC 2.4.2.4) purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC(50) values below 1 microM were selected. Out of them, four compounds strongly inhibited the enzyme with IC(50) values lying in a range of 11-45 nM. These most potent compounds might be bi-substrate analogues.
Related Publications
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
January 2007,
Nucleosides, nucleotides & nucleic acids,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
March 2021,
The journal of physical chemistry. B,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
March 1995,
Journal of medicinal chemistry,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
March 2014,
European journal of medicinal chemistry,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
March 2004,
Current opinion in drug discovery & development,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
March 2012,
Journal of medicinal chemistry,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
October 2014,
Organic & biomolecular chemistry,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
March 1970,
Biochimica et biophysica acta,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
June 2010,
International urology and nephrology,
Petr Kocalka, and
Dominik Rejman, and
Václav Vanek, and
Markéta Rinnová, and
Ivana Tomecková, and
Sárka Králíková, and
Magdalena Petrová, and
Ondrej Páv, and
Radek Pohl, and
Milos Budesínský, and
Radek Liboska, and
Zdenek Tocík, and
Natalya Panova, and
Ivan Votruba, and
Ivan Rosenberg
April 2010,
Chemical biology & drug design,
