BIOMAT Database Logo BIOMAT Database Logo

[Cytoplasmic receptors of steroid hormones and clinico-morphological characteristics of skin melanoma]. 1991

E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov

Receptors of estrogens (ER), progesterone (PR), glucocorticoids (GR) and androgens (AR) were assayed in samples obtained from 142 patients with malignant melanoma. GR were observed most often (57% of cases), the percentage being significantly lower for ER (25%) and PR (18%) and extremely low for AR (4%). The occurrence of GR was significantly higher in metastasis to lymph nodes (69%) and soft tissue (67%) as compared to primary tumor (39%). It was higher in acro-lentiginous melanoma (83%) than in superficially extending (30%) or nodular one (33%). GR occurrence rose with the increase in level of invasion (from 30% for level III to 71% for level V) and tumor thickness. In application of adjuvant chemotherapy, patients with GR--negative tumors tended to survive better than those with GR--positive tumors whereas in the chemotherapy-naive group, GR--positive tumors carried better prognosis.

UI MeSH Term Description Entries
D008297 Male Males
D008545 Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011944 Receptors, Androgen Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA. Androgen Receptors,5 alpha-Dihydrotestosterone Receptor,Androgen Receptor,Dihydrotestosterone Receptors,Receptor, Testosterone,Receptors, Androgens,Receptors, Dihydrotestosterone,Receptors, Stanolone,Stanolone Receptor,Testosterone Receptor,5 alpha Dihydrotestosterone Receptor,Androgens Receptors,Receptor, 5 alpha-Dihydrotestosterone,Receptor, Androgen,Receptor, Stanolone,Stanolone Receptors,alpha-Dihydrotestosterone Receptor, 5
D011960 Receptors, Estrogen Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important. Estrogen Receptor,Estrogen Receptors,Estrogen Nuclear Receptor,Estrogen Receptor Type I,Estrogen Receptor Type II,Estrogen Receptors Type I,Estrogen Receptors Type II,Receptor, Estrogen Nuclear,Receptors, Estrogen, Type I,Receptors, Estrogen, Type II,Nuclear Receptor, Estrogen,Receptor, Estrogen
D011965 Receptors, Glucocorticoid Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example. Corticoid Type II Receptor,Glucocorticoid Receptors,Glucocorticoids Receptor,Corticoid II Receptor,Corticoid Type II Receptors,Glucocorticoid Receptor,Receptors, Corticoid II,Receptors, Corticoid Type II,Receptors, Glucocorticoids,Corticoid II Receptors,Glucocorticoids Receptors,Receptor, Corticoid II,Receptor, Glucocorticoid,Receptor, Glucocorticoids
D011980 Receptors, Progesterone Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives. Progesterone Receptors,Progestin Receptor,Progestin Receptors,Receptor, Progesterone,Receptors, Progestin,Progesterone Receptor,Receptor, Progestin
D011987 Receptors, Steroid Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes. Corticosteroid Receptors,Receptors, Corticosteroid,Steroid Receptors,Corticosteroid Receptor,Receptors, Steroids,Steroid Receptor,Receptor, Corticosteroid,Receptor, Steroid,Steroids Receptors
D003593 Cytoplasm The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990) Protoplasm,Cytoplasms,Protoplasms

Related Publications

E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
Receptors for steroid hormones in human melanoma.
January 1976, Surgical forum,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
[Determination of cytoplasmic receptors for specific steroid hormones. II) Androgen receptor].
January 1979, Bollettino della Societa italiana di biologia sperimentale,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
[Determination of cytoplasmic receptors for specific steroid hormones. I) Estrogen receptor].
January 1979, Bollettino della Societa italiana di biologia sperimentale,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
[Determination of cytoplasmic receptors for specific steroid hormones. III) Progestin receptor].
January 1979, Bollettino della Societa italiana di biologia sperimentale,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
[Measurement of cytoplasmic receptors specific for steroid hormones. IV) Glucocorticoid receptor].
February 1979, Bollettino della Societa italiana di biologia sperimentale,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
[Receptors of steroid hormones].
January 1973, Postepy biochemii,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
[Clinico-morphological characteristics of basal cell carcinoma of head and neck skin].
January 1987, Voprosy onkologii,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
Steroid hormones and their receptors.
May 1973, The Journal of endocrinology,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
Steroid hormones, receptors, and antagonists.
April 1996, Annals of the New York Academy of Sciences,
E S Gershteĭn, and B B Taĭlakov, and K D Smirnova, and Z V Kuz'mina, and S M Parshikhova, and L V Demidov
[Relationship between androgen and estrogen receptors and clinico-morphological characteristics of prostatic cancer].
January 1983, Arkhiv patologii,
Copied contents to your clipboard!