Biomaterial Database

ACTH 4-10 and short-term memory. 1976

R L Dornbush, and O Nikolovski

ACTH 4-10 is a polypeptide which is a fragment of pituitary ACTH and was synthesized by Greven. Studies suggest that it does not have the endocrine or metabolic effects characteristic of ACTH but may have a specific enhancing effect on memory or possibly on attention. Several tasks which emphasized the storage phase of the memory process were presented to young adult (mean age: 23.6 yr) male volunteers. Subjects received 30 mg ACTH 4-10 subcutaneously and their performance on these tasks was compared against placebo. ACTH 4-10 had no effect on unisensory short-term memory. It did, however, impair performance of a bisensory short-term memory task. The bisensory task is complex and requires considerable focussing of attention. It is suggested that ACTH 4-10 may act on the arousal processes which energize behavior unselectively rather than result in focussing of attention.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008570	Memory, Short-Term	Remembrance of information for a few seconds to hours.	Immediate Recall,Memory, Immediate,Working Memory,Memory, Shortterm,Immediate Memories,Immediate Memory,Immediate Recalls,Memories, Immediate,Memories, Short-Term,Memories, Shortterm,Memory, Short Term,Recall, Immediate,Recalls, Immediate,Short-Term Memories,Short-Term Memory,Shortterm Memories,Shortterm Memory,Working Memories
D010446	Peptide Fragments	Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.	Peptide Fragment,Fragment, Peptide,Fragments, Peptide
D006309	Hearing	The ability or act of sensing and transducing ACOUSTIC STIMULATION to the CENTRAL NERVOUS SYSTEM. It is also called audition.	Audition
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000324	Adrenocorticotropic Hormone	An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).	ACTH,Adrenocorticotropin,Corticotropin,1-39 ACTH,ACTH (1-39),Adrenocorticotrophic Hormone,Corticotrophin,Corticotrophin (1-39),Corticotropin (1-39),Hormone, Adrenocorticotrophic,Hormone, Adrenocorticotropic
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D013647	Task Performance and Analysis	The detailed examination of observable activity or behavior associated with the execution or completion of a required function or unit of work.	Critical Incident Technique,Critical Incident Technic,Task Performance,Task Performance, Analysis,Critical Incident Technics,Critical Incident Techniques,Incident Technic, Critical,Incident Technics, Critical,Incident Technique, Critical,Incident Techniques, Critical,Performance, Analysis Task,Performance, Task,Performances, Analysis Task,Performances, Task,Task Performances,Task Performances, Analysis,Technic, Critical Incident,Technics, Critical Incident,Technique, Critical Incident,Techniques, Critical Incident
D014706	Verbal Learning	Learning to respond verbally to a verbal stimulus cue.	Learning, Verbal,Learnings, Verbal,Verbal Learnings
D014785	Vision, Ocular	The process in which light signals are transformed by the PHOTORECEPTOR CELLS into electrical signals which can then be transmitted to the brain.	Vision,Light Signal Transduction, Visual,Ocular Vision,Visual Light Signal Transduction,Visual Phototransduction,Visual Transduction,Phototransduction, Visual,Transduction, Visual