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The research investigated the effects of acute ACTH 1-17 administration on plasma cortisol, short-term memory, anxiety state, blood pressure and heart rate. In a double blind crossover design, healthy volunteers were serially evaluated at 5 min, 20 min, 40 min, 60 min after injection of ACTH 1-17 or placebo in separate sessions. Results show that ACTH 1-17 produced, in addition to an increase in plasma cortisol (5 min - 60 min), significant improvements in short-term memory (5 min), a reduction in anxiety (20 min and 40 min), and an increase in systolic (5 min and 20 min) and diastolic blood pressure (5 min). If confirmed by other studies, the short-term memory effect of ACTH 1-17 at 5 min after i.v. could suggest a central action of the peptide, and confirm the role of HPA axis as a modulator of performance and emotional arousal during acute environmental changes.
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
January 1999,
Electroencephalography and clinical neurophysiology. Supplement,
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
June 1998,
Clinical autonomic research : official journal of the Clinical Autonomic Research Society,
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
January 2000,
American journal of physiology. Regulatory, integrative and comparative physiology,
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
January 2000,
Studies in health technology and informatics,
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
May 2007,
Psychiatry research,
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
January 1976,
Pharmacology, biochemistry, and behavior,
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
July 1990,
Clinical physiology (Oxford, England),
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
December 1991,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
December 2008,
Resuscitation,
P Pancheri, and
M Biondi, and
R Delle Chiaie, and
A Maione Marchini, and
A Fierro, and
C Giovannini
January 2017,
Computational and mathematical methods in medicine,
