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In 20 mid-trimester abortion seekers induced by extra-amniotic instillation of normal saline, serial estimation of prostaglandin F2 alpha (PGF2 alpha) in the plasma and extra-ovular space were carried out. It was observed that PGF2 alpha was undetectable in both plasma and the extra-ovular space prior to the onset of induction, and was first detected in the extra-ovular fluid 2 hours after the onset of induction, prior to oxytocin infusion. In the subsequent samples, the prostaglandin concentration in plasma as well as in the extra-ovular fluid was found to rise, with levels in the latter showing a more significant rise with time as compared to the former. Thus, this study confirms the hypothesis that the mechanism of action of extra-ovular normal saline instillation in mid-trimester termination of pregnancy is the result of separation of fetal membranes from the uterine wall, leading to the release of prostaglandins which, in turn, causes uterine contractions leading to abortion.
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
June 1974,
American journal of obstetrics and gynecology,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
September 1984,
American journal of obstetrics and gynecology,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
November 1973,
British medical journal,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
February 1973,
American journal of obstetrics and gynecology,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
September 1979,
Southern medical journal,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
February 1978,
Contraception,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
April 1978,
Indian journal of pathology & microbiology,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
January 1979,
International surgery,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
August 1981,
Prostaglandins,
K Chandra, and
I Gupta, and
V Dhawan, and
N K Ganguly
February 1978,
Fortschritte der Medizin,
