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A single intra-amniotic injection of (15S)-15 methyl prostaglandin F2 alpha (THAM) was used to induce second trimester abortion in five patients. Serial levels of (15S)-15 methyl prostaglandin F2 alpha were subsequently measured in amniotic fluid and plasma by radioimmunoassay. The slow removal of this drug from the amniotic fluid was documented. Plasma levels of (15S)-15 methyl prostaglandin F2 alpha increased fourfold to sevenfold after clinical rupture of the membranes in three patients, supporting the fact that prostaglandins are well absorbed from the vagina. Because this analogue of prostaglandin can cause marked peripheral bronchoconstriction when administered systemically, it is best to avoid its use in patients with a history of asthma.
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
April 1979,
Journal of obstetrics and gynaecology of India,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
January 1998,
Journal of perinatology : official journal of the California Perinatal Association,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
January 1997,
Obstetrics and gynecology,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
November 1999,
American journal of obstetrics and gynecology,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
March 1975,
Contraception,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
December 1984,
Asia-Oceania journal of obstetrics and gynaecology,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
April 1983,
Contraceptive delivery systems,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
February 1984,
Journal of pharmaceutical sciences,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
July 1991,
Contraception,
L Weinstein, and
W Droegemueller, and
J Cornette, and
B Greer, and
G Gutknecht
June 1974,
American journal of obstetrics and gynecology,
