[Modeling of the semi-circular canal, application to labyrinthine hydrops]. 1991

C Kopp, and E Njeugna, and J L Eichhorn, and A Gentine
Institut de Mécanique des Fluides URA CNRS 854, Université Louis Pasteur, Strasbourg.

The angular accelerometer of vertebrates, the semi circular canal, is a pressure gage. The transformation, acceleration to pressure, is due to the inertia of the endolymph. In the 0 to 1 Hz frequency interval, the endolymph-cupula system can be described by a second order, localised parameter model with two real time constants. This mechanical model explains the occurr]nces of the vestibular-ocular reflex during rotatory stimulations. However, some features of the response to caloric stimulations cannot be explained from this unique point of view. To correspond to these features, the SCC has to be considered as an inflatable structure, sensitive to weak pressure variations between the endolymph and perilymph. Different parameters of the mechanical model, the internal radius of the membranous canal, the dimension of the cupula and its elasticity coefficient depend on the inflating pressure. Ménière's disease is caracterised by hydrops, i.e. an increase of the pressure in the membranous SCC. The different mechanisms related to this hydrops, in particular introducing the inflating pressure as a second input to the ampular system, associated to a new concept of the mechanoneural transduction can explain the classical vestibular symptoms of Ménière's disease. Therefore, this overall mechanical model of the SCC indicates that hydrops is the mechanical cause of Ménière's disease and the primary cause is more likely to be a defect in the regulation loop of the inflating pressure.

UI MeSH Term Description Entries
D007759 Labyrinth Diseases Pathological processes of the inner ear (LABYRINTH) which contains the essential apparatus of hearing (COCHLEA) and balance (SEMICIRCULAR CANALS). Inner Ear Disease,Ear Disease, Inner,Ear Diseases, Inner,Inner Ear Diseases,Labyrinth Disease
D008575 Meniere Disease A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops. Meniere's Disease,Meniere's Syndrome,Vertigo, Aural,Auditory Vertigo,Aural Vertigo,Ménière Disease,Ménière's Disease,Ménière's Vertigo,Otogenic Vertigo,Auditory Vertigos,Disease, Meniere,Disease, Meniere's,Disease, Ménière,Disease, Ménière's,Diseases, Ménière,Diseases, Ménière's,Meniere Syndrome,Menieres Disease,Menieres Syndrome,Ménière Diseases,Ménière Vertigo,Ménière's Diseases,Ménière's Vertigos,Ménières Disease,Ménières Vertigo,Otogenic Vertigos,Syndrome, Meniere's,Vertigo, Auditory,Vertigo, Ménière's,Vertigo, Otogenic,Vertigos, Auditory,Vertigos, Ménière's,Vertigos, Otogenic
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001703 Biophysics The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things. Mechanobiology
D012665 Semicircular Canals Three long canals (anterior, posterior, and lateral) of the bony labyrinth. They are set at right angles to each other and are situated posterosuperior to the vestibule of the bony labyrinth (VESTIBULAR LABYRINTH). The semicircular canals have five openings into the vestibule with one shared by the anterior and the posterior canals. Within the canals are the SEMICIRCULAR DUCTS. Semi-Circular Canals,Canal, Semi-Circular,Canal, Semicircular,Semi Circular Canals,Semi-Circular Canal,Semicircular Canal
D055592 Biophysical Phenomena The physical characteristics and processes of biological systems. Biophysical Concepts,Biophysical Processes,Biophysical Phenomenon,Biophysical Process,Biophysical Concept,Concept, Biophysical,Concepts, Biophysical,Phenomena, Biophysical,Phenomenon, Biophysical,Process, Biophysical,Processes, Biophysical

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