Effect of reversible inactivation of the reuniens nucleus on spatial learning and memory in rats using Morris water maze task. 2009

Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
Neuroscience Research Center and Department of Physiology, Faculty of medicine, Shahid Beheshti University (Medical Sciences), Tehran, Iran.

The involvement of thalamic midline nuclei (MLN) in early stage of Alzheimer's disease and in diencephalic amnesia has drawn attention to the connectivity between the nucleus reuniens (RE) and structures of medial temporal lobe. RE is major source of thalamic afferents to the hippocampus and has been shown to exert powerful excitatory action on CA1 of hippocampus, which is supposed to be involved in learning and memory processes. However, the role of the RE on spatial memory is a controversial issue. The present study was designed to evaluate the role of the RE in acquisition, consolidation and retrieval of spatial reference memory (RM) and working memory (WM). We assessed the effect of reversible inactivation of RE with tetracaine (0.5 microl, 2%) on different stages of memory. Rats were trained on RM and WM versions of the Morris water maze (MWM) task. RE was inactivated before or immediately after training or before the probe trial of retrieval tests. The data showed that reversible inactivation of the RE significantly impaired both RM and WM versions of MWM. Therefore, it seems that nucleus reuniens of thalamus plays a role in spatial RM and WM version of the MWM task in rats.

UI MeSH Term Description Entries
D008297 Male Males
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D008845 Microinjections The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes. Microinjection
D009434 Neural Pathways Neural tracts connecting one part of the nervous system with another. Neural Interconnections,Interconnection, Neural,Interconnections, Neural,Neural Interconnection,Neural Pathway,Pathway, Neural,Pathways, Neural
D004924 Escape Reaction Innate response elicited by sensory stimuli associated with a threatening situation, or actual confrontation with an enemy. Flight Reaction,Escape Reactions,Flight Reactions,Reaction, Escape,Reaction, Flight,Reactions, Escape,Reactions, Flight
D005106 Exploratory Behavior The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity. Curiosity,Novelty-Seeking Behavior,Behavior, Exploratory,Behavior, Novelty-Seeking,Behaviors, Exploratory,Behaviors, Novelty-Seeking,Curiosities,Exploratory Behaviors,Novelty Seeking Behavior,Novelty-Seeking Behaviors
D000779 Anesthetics, Local Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. Anesthetics, Conduction-Blocking,Conduction-Blocking Anesthetics,Local Anesthetic,Anesthetics, Topical,Anesthetic, Local,Anesthetics, Conduction Blocking,Conduction Blocking Anesthetics,Local Anesthetics,Topical Anesthetics
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013037 Spatial Behavior Reactions of an individual or groups of individuals with relation to the immediate surrounding area including the animate or inanimate objects within that area. Behavior, Spatial,Behaviors, Spatial,Spatial Behaviors
D013550 Swimming An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.

Related Publications

Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
September 2000, Behavioural brain research,
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
November 2004, Brain research,
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
March 2005, Medical science monitor : international medical journal of experimental and clinical research,
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
June 2008, Neuroscience,
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
January 2015, PloS one,
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
January 2010, Pharmaceutical statistics,
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
May 2004, Current protocols in neuroscience,
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
June 1988, Pharmacology, biochemistry, and behavior,
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
January 2011, Methods in molecular biology (Clifton, N.J.),
Farzaneh Ghiafeh Davoodi, and Fereshteh Motamedi, and Nasser Naghdi, and Esmaeil Akbari
December 2007, CSH protocols,
Copied contents to your clipboard!