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Intraventricular administration of the enkephalin analog, [D-Ala2]-metenkephalin, induces profound and long-lasting analgesia, as well as other opiate-like behavioral effects in the rat. This analgesia was highly dose dependent, of much greater magnitude, and about 30 times longer lasting than that produced by the naturally occurring peptide, methionine-enkephalin. The behavioral effects of the [D-Ala2] analog could be completely reversed by the opiate antagonist, naloxone, suggesting that these effects were mediated by opiate receptors. Systemic administration of naloxone alone resulted in a significant increase in pain sensitivity. These findings support the view that endogenous opiate systems may play an important role in modulating pain sensitivity.
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
January 1988,
Doklady Akademii nauk SSSR,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
December 1980,
Proceedings of the National Academy of Sciences of the United States of America,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
September 1982,
International journal of peptide and protein research,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
April 1995,
Bioorganicheskaia khimiia,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
May 1981,
European journal of pharmacology,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
November 1976,
Molecular pharmacology,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
January 1977,
European journal of pharmacology,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
September 1979,
Pharmacology, biochemistry, and behavior,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
April 1991,
Fish physiology and biochemistry,
J M Walker, and
G G Berntson, and
C A Sandman, and
D H Coy, and
A V Schally, and
A J Kastin
December 1980,
The Journal of clinical endocrinology and metabolism,
