-transparent.png){kind=logo}
Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family. 1991
Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, U.K.
A new human liver UDP-glucuronosyltransferase (HlugP4) has been cloned and expressed in cell culture. The expressed enzyme has a molecular mass of 56 kDa and preferentially catalysed the glucuronidation of halogenated and bulky alkyl phenols. The C-terminal half of the sequence (246 amino acids) is 96% identical with the same portion of HlugP1, whereas the N-terminal half of the deduced protein sequences are only 38% identical. These results suggest that the two isoenzymes may be derived from the same gene by differential splicing of the gene product.
Related Publications
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
May 1997,
Pharmaceutical research,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
June 1995,
Molecular pharmacology,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
March 2001,
Life sciences,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
October 1997,
Archives of pharmacal research,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
March 1987,
The Biochemical journal,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
April 1995,
Protein expression and purification,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
July 1993,
Biochemical and biophysical research communications,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
January 1991,
The Journal of biological chemistry,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
August 1996,
Biochemical and biophysical research communications,
R Wooster, and
L Sutherland, and
T Ebner, and
D Clarke, and
O Da Cruz e Silva, and
B Burchell
February 1993,
Biochemical and biophysical research communications,
