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Kikuchi-Fujimoto disease and systemic lupus erythematosus: the EBV connection? 2009

Lazaros Gionanlis, and Marios Katsounaros, and Gerasimos Bamihas, and Stelios Fragidis, and Panagiota Veneti, and Kostas Sombolos
Department of Nephrology, General Hospital G. Papanikolaou, Thessaloniki, Greece. lgionanlis@yahoo.com

Kikuchi-Fujimoto disease (KFD) is a benign and self-limited disease of unknown etiology that affects mainly young women. It presents with localized lymphadenopathy, usually cervical, accompanied with fever, night sweats, and leucopenia. KFD has been rarely described in association with autoimmune disorders, mainly systemic lupus erythematosus (SLE). We report the case of a young patient presenting with KFD coinciding with SLE. The association of KFD and SLE is reviewed. Moreover, a possible pathogenetic role of Ebstein-Barr virus linking the two clinical entities is discussed.

UI MeSH Term Description Entries
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D004854 Herpesvirus 4, Human The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies. Burkitt Herpesvirus,Burkitt Lymphoma Virus,E-B Virus,EBV,Epstein-Barr Virus,Human Herpesvirus 4,Infectious Mononucleosis Virus,Burkitt's Lymphoma Virus,HHV-4,Herpesvirus 4 (gamma), Human,Burkitts Lymphoma Virus,E B Virus,E-B Viruses,Epstein Barr Virus,Herpesvirus, Burkitt,Infectious Mononucleosis Viruses,Lymphoma Virus, Burkitt,Mononucleosis Virus, Infectious,Mononucleosis Viruses, Infectious
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D055815 Young Adult A person between 19 and 24 years of age. Adult, Young,Adults, Young,Young Adults
D020031 Epstein-Barr Virus Infections Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY). EBV Infections,Epstein-Barr Virus Infection,Herpesvirus 4 Infections, Human,Human Herpes Virus 4 Infections,Human Herpesvirus 4 Infections,Infections, EBV,Infections, Epstein-Barr Virus,EBV Infection,Epstein Barr Virus Infection,Epstein Barr Virus Infections,Infection, EBV,Infection, Epstein-Barr Virus,Virus Infection, Epstein-Barr,Virus Infections, Epstein-Barr
D020042 Histiocytic Necrotizing Lymphadenitis Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue. Kikuchi Disease,Lymphadenitis, Histiocytic Necrotizing,Histiocytic Necrotising Lymphadenitis,Kikuchi Necrotizing Lymphadenitis,Kikuchi's Disease,Kikuchi-Fujimoto Disease,Kikuchi-Fujimoto's Disease,Nosocomial Kikuchi's Disease,Disease, Kikuchi,Disease, Kikuchi's,Disease, Kikuchi-Fujimoto,Disease, Kikuchi-Fujimoto's,Histiocytic Necrotising Lymphadenitides,Kikuchi Fujimoto Disease,Kikuchi Fujimoto's Disease,Kikuchi's Disease, Nosocomial,Kikuchi-Fujimotos Disease,Kikuchis Disease,Lymphadenitides, Histiocytic Necrotising,Lymphadenitis, Histiocytic Necrotising,Lymphadenitis, Kikuchi Necrotizing,Necrotising Lymphadenitides, Histiocytic,Necrotising Lymphadenitis, Histiocytic,Necrotizing Lymphadenitis, Histiocytic,Necrotizing Lymphadenitis, Kikuchi,Nosocomial Kikuchi Disease,Nosocomial Kikuchis Disease

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