-transparent.png){kind=logo}
The effect of Clostridium perfringens alpha toxin on contraction induced by electric stimulation of isolated guinea-pig diaphragm was investigated. The toxin inhibited electrically stimulated contraction of the tissue in a dose- and incubation time-dependent manner. Tetrodotoxin resulted in no effect of the action of the toxin. Nifedipine dose-dependently delayed the action of the toxin, but verapamil and diltiazem did not. On the other hand, treatment of the toxin with N-acetylimidazole caused significant reduction of the inhibitory activity of the toxin on contraction, but did not cause significant loss of phospholipase C activity (PN activity) as measured by hydrolysis of p-nitrophenylphosphorylcholine. The data showed that the toxin impairs contraction of isolated guinea-pig diaphragm.
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
January 1990,
Toxicon : official journal of the International Society on Toxinology,
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
July 1986,
British journal of pharmacology,
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
January 1985,
Toxicon : official journal of the International Society on Toxinology,
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
January 1993,
Microbiology and immunology,
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
April 1999,
Anaerobe,
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
February 1977,
Japanese journal of medical science & biology,
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
November 1945,
Journal of immunology (Baltimore, Md. : 1950),
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
September 1994,
Nihon saikingaku zasshi. Japanese journal of bacteriology,
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
April 1989,
FEMS microbiology letters,
J Sakurai, and
Y Tsuchiya, and
S Ochi, and
Y Fujii
January 2013,
Current pharmaceutical biotechnology,
