Biomaterial Database

Intracerebroventricular injection of arginine vasotocin induces elevation of blood pressure in anesthetized trout. 1991

J C Le Mevel, and D Mabin, and H Vaudry

Laboratoire de Médecine Expérimentale, Faculté de Médecine, Brest, France.

The present investigation assessed the ability of the neurohypophysial nonapeptide arginine vasotocin (AVT) to centrally regulate the cardiovascular activity in fish. Intracerebroventricular (ICV) injection of AVT (0.4 to 50 ng/kg b.wt.) in anesthetized trout resulted in a dose-related increase in blood pressure (BP) without any consistent changes in heart rate. For doses of AVT ranging from 2 to 50 ng/kg b.wt., BP remained elevated during at least 25 min after ICV injection. Systemic (intraarterial) administration of the same doses of AVT appeared to be less efficient than ICV injection, except for the highest dose (50 ng/kg) which evoked a similar rise in BP as that observed after ICV administration. In contrast to AVT, a high concentration of neuropeptide Y (10 micrograms/kg b.wt., ICV) caused only a slight increase of BP. The results suggest that AVT acts centrally to regulate BP in fish. These data, together with the widespread distribution of AVT-immunoreactive fibers and AVT binding sites in the brain, support the notion that, in fish, AVT may play neuromodulator and/or neurotransmitter functions.

UI	MeSH Term	Description	Entries
D007269	Injections, Intra-Arterial	Delivery of drugs into an artery.	Injections, Intraarterial,Intra-Arterial Injections,Intraarterial Injections,Injection, Intra-Arterial,Injection, Intraarterial,Injections, Intra Arterial,Intra Arterial Injections,Intra-Arterial Injection,Intraarterial Injection
D007276	Injections, Intraventricular	Injections into the cerebral ventricles.	Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D008297	Male		Males
D009478	Neuropeptide Y	A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.	Neuropeptide Y-Like Immunoreactive Peptide,Neuropeptide Tyrosine,Neuropeptide Y Like Immunoreactive Peptide,Tyrosine, Neuropeptide
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D005260	Female		Females
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014337	Trout	Various fish of the family SALMONIDAE, usually smaller than salmon. They are mostly restricted to cool clear freshwater. Some are anadromous. They are highly regarded for their handsome colors, rich well-flavored flesh, and gameness as an angling fish. The genera Salvelinus, Salmo, and ONCORHYNCHUS have been introduced virtually throughout the world.	Chars,Salvelinus,Char