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Vigorous physical activity and lovastatin (Mevacor) a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, have both been independently associated with elevated creatine kinase (CK) levels. To determine the effect of lovastatin plus exercise on serum CK activity, we measured CK levels before and after maximal treadmill exercise in 14 men (51.6 +/- 17.3 years, mean +/- SD) and 6 women (48.5 +/- 7.4 years) before and after 4 weeks of lovastatin treatment (20 mg/d). Blood samples were obtained before, immediately after, and 24 hours after exercise. Individual subjects were exercised for the same duration on each test. Preexercise CK levels and the average CK response to treadmill exercise did not differ before and after lovastatin treatment. In two men taking lovastatin, however, CK levels increased by 183% and 242% 24 hours after exercise during lovastatin administration. We conclude that low-dose lovastatin treatment plus exercise does not affect average CK activity but that this combination may markedly increase CK levels in certain individuals.
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
January 1999,
The American journal of Chinese medicine,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
August 1965,
British medical journal,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
July 1965,
British medical journal,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
October 1976,
Archives of general psychiatry,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
January 1985,
European journal of applied physiology and occupational physiology,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
June 1965,
British medical journal,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
January 1981,
Enzyme,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
January 1971,
Biology of the neonate,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
August 1983,
Clinica chimica acta; international journal of clinical chemistry,
P D Thompson, and
P A Gadaleta, and
S Yurgalevitch, and
E Cullinane, and
P N Herbert
August 1996,
Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering,
