Biomaterial Database

Effects of conditioning on exertional rhabdomyolysis and serum creatine kinase after severe exercise. 1981

J H Maxwell, and C M Bloor

This study determined the effects of different conditioning levels on exertional rhabdomyolysis after severe exercise. 15 well-conditioned men were randomly divided into three conditioning groups, i.e. 0, 4 and 8 miles on alternate days for 1 month. They were physically stressed by running 14 miles at 8 min/mile after 1 month of training. The effects of the different levels of conditioning on exertional rhabdomyolysis after the test run were determined by assaying serum samples for creatine kinase (CK) and myoglobin levels. Serum CK levels increased 98-294% above pre-conditioning control values after the 14-mile test run while serum myoglobin levels increased 52-405%. The most marked increases occurred in those subjects who trained less than 8 miles on alternate days. These results suggest that these quantitative indices are useful in determining the amount of conditioning necessary to prevent significant rhabdomyolysis after severe exercise.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008297	Male		Males
D009135	Muscular Diseases	Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.	Muscle Disorders,Myopathies,Myopathic Conditions,Muscle Disorder,Muscular Disease,Myopathic Condition,Myopathy
D009211	Myoglobin	A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.
D003402	Creatine Kinase	A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.	Creatine Phosphokinase,ADP Phosphocreatine Phosphotransferase,ATP Creatine Phosphotransferase,Macro-Creatine Kinase,Creatine Phosphotransferase, ATP,Kinase, Creatine,Macro Creatine Kinase,Phosphocreatine Phosphotransferase, ADP,Phosphokinase, Creatine,Phosphotransferase, ADP Phosphocreatine,Phosphotransferase, ATP Creatine
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults