-transparent.png){kind=logo}
Incubation of aldosterone with confluent layers of A6 (toad kidney) cells leads to its hydroxylation at the 6 beta-position. 6 beta-Hydroxyaldosterone is the major metabolite when the incubation is carried out at pH 6.8, whereas the product comprises 6 beta-hydroxy-17-isoaldosterone accompanied by some 6 beta-hydroxyapoaldosterone at pH 7.4. All products were identified by high-field 1H nuclear magnetic resonance spectroscopy. Control experiments indicated that the side-chain isomerization to form the 17-iso and apo derivatives occurs after the cytochrome P 450-dependent synthesis of 6 beta-hydroxyaldosterone.
Related Publications
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
March 1985,
Endocrinology,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
April 1991,
Endocrinologia japonica,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
July 1999,
Pflugers Archiv : European journal of physiology,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
July 1995,
Steroids,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
September 1983,
The American journal of physiology,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
June 1995,
Annals of the New York Academy of Sciences,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
September 1981,
The American journal of physiology,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
September 1985,
The American journal of physiology,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
March 2000,
Toxicology and applied pharmacology,
D J Morris, and
S A Latif, and
T J Conca, and
L T Wei, and
C O Watlington, and
D N Kirk, and
H C Toms, and
C H Shackleton
July 1984,
The American journal of physiology,
