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Inhibitory non-adrenergic non-cholinergic (NANC) nerves are thought to be important in the autonomic innervation of the gastrointestinal tract and other organ systems. The nature of their neurotransmitter is still debated. Speculation that nitric oxide (NO), formed from L-arginine in neuronal structures and other cells, could act as a neurotransmitter, is not yet supported by demonstration of its release upon nerve stimulation. Using a superfusion bioassay, we report the release of a vasorelaxant factor upon stimulation of the NANC nerves in the canine ileocolonic junction. Several pieces of evidence, including the selectivity of the bioassay tissues, chemical instability, inactivation by superoxide anion and haemoglobin, inhibition by NG-nitro-L-arginine (L-NNA) and potentiation by L-arginine all indicated that NO accounted for the biological activity of this transferable NANC factor.
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
January 2019,
British journal of pharmacology,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
January 1992,
Japanese journal of pharmacology,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
January 1992,
Japanese journal of pharmacology,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
December 1995,
Nihon Kyobu Shikkan Gakkai zasshi,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
November 1980,
Nature,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
April 1995,
Journal of autonomic pharmacology,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
December 1997,
Comparative biochemistry and physiology. Part A, Physiology,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
April 1992,
British journal of pharmacology,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
February 1997,
Journal of gastroenterology,
H Bult, and
G E Boeckxstaens, and
P A Pelckmans, and
F H Jordaens, and
Y M Van Maercke, and
A G Herman
January 2014,
Pharmacology,
