-transparent.png){kind=logo}
Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs. 2009
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan. ikejim@osaka-ohtani.ac.jp
Several nucleoside analogs containing a methylene group instead of a 5'-O atom were synthesized to study the effect of the 5'-modification of nucleoside analogs on their anti-HCV activity. Among the analogs, a 5'-phenacyl analog exhibited good anti-HCV activity with an EC(50) of 15.1 muM. This compound is hypothesized to function via a novel type of mechanism that does not involve the conventional 5'-O-triphosphorylation process.
Related Publications
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
July 2010,
Bioorganic & medicinal chemistry letters,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
January 2005,
Nucleosides, nucleotides & nucleic acids,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
November 1996,
Antiviral research,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
December 2010,
Bioorganic & medicinal chemistry letters,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
June 1987,
Biochemical pharmacology,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
January 1993,
Nucleic acids symposium series,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
April 1974,
Journal of medicinal chemistry,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
May 2013,
Bioorganic & medicinal chemistry,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
September 2016,
Nucleosides, nucleotides & nucleic acids,
Masahiro Ikejiri, and
Takayuki Ohshima, and
Akemi Fukushima, and
Kunitada Shimotohno, and
Tokumi Maruyama
December 2017,
Bioorganic & medicinal chemistry letters,
