BIOMAT Database Logo BIOMAT Database Logo

Inhibitory effect of pancreastatin on pancreatic exocrine secretions. Pancreastatin inhibits central vagal nerve stimulation. 1990

K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.

The effects of the C-terminal fragment of rat pancreastatin on exocrine pancreatic secretions induced by several neural stimulations [IV injection of 75 or 15 mg/kg of 2-deoxy-D-glucose (central vagal nerve stimulation), injection of 2 mg of cisapride (proposed to elicit acetylcholine release from cholinergic nerve ending), and infusion of 1 or 3 mg.kg-1.h-1 of bethanechol (direct stimulation of acinar cells)] were examined in conscious rats. Rats with external bile and pancreatic fistulae were used. All the stimulations caused significant increases in pancreatic exocrine secretions. Pancreastatin at 100 pmol.kg-1.h-1 inhibited pancreatic secretions stimulated by IV injection of 2-deoxy-D-glucose but not those induced by the infusion of bethanechol or the injection of cisapride. Because these findings showed that pancreastatin inhibited pancreatic secretions induced by central vagal nerve stimulation, the effect of pancreastatin on cholecystokinin-stimulated pancreatic secretions in vagotomized rats was examined. Pancreastatin at 100 pmol.kg-1.h-1 did not inhibit pancreatic secretions stimulated by cholecystokinin octapeptide at 100 pmol.kg-1.h-1 in conscious rats after bilateral truncal vagotomy. These results suggest that pancreastatin inhibits pancreatic exocrine secretions by inhibiting vagal efferent nerve activity.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D010179 Pancreas A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010187 Pancreatic Hormones Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide. Hormones, Pancreatic
D010880 Piperidines A family of hexahydropyridines.
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002766 Cholecystokinin A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety. Pancreozymin,CCK-33,Cholecystokinin 33,Uropancreozymin
D003847 Deoxyglucose 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity. 2-Deoxy-D-glucose,2-Deoxyglucose,2-Desoxy-D-glucose,2 Deoxy D glucose,2 Deoxyglucose,2 Desoxy D glucose
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Effect of pancreastatin on pancreatic endocrine and exocrine secretion.
January 1989, Pancreas,
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
The effect of electrical vagal stimulation on canine pancreatic exocrine function.
April 1975, Surgery,
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Effect of secretion on vagal stimulation-evoked exocrine pancreatic secretion in the rat.
March 1993, Revista espanola de fisiologia,
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Pancreastatin inhibits insulin secretion and exocrine pancreatic secretion in the pig.
June 1990, Diabetes research (Edinburgh, Scotland),
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Enhancement by atropine of the pancreatic exocrine secretions evoked by vagal stimulation in the pithed rat.
September 1993, The Journal of physiology,
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Effect of the exocrine pancreatic secretions on iron absorption.
December 1967, Gut,
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Stimulation of exocrine secretions of pancreatic allograft after duodenocystostomy.
June 1992, Transplantation proceedings,
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Potentiated effect of vagal stimulation and hormonal agents on pancreatic exocrine secretion in dogs.
June 1991, Science in China. Series B, Chemistry, life sciences & earth sciences,
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Effect of somatostatin on meal-stimulated pancreatic exocrine secretions in dogs.
January 1977, Diabetes,
K Miyasaka, and A Funakoshi, and K Kitani, and H Tamamura, and S Funakoshi, and N Fujii
Inhibitory effect of ethanol on canine exocrine pancreatic secretion.
October 1972, Gastroenterology,
Copied contents to your clipboard!