-transparent.png){kind=logo}
We measured the number and size of foci of altered hepatocytes induced after 8 weeks by diethylnitrosamine (DENA) in the liver of rats pretreated with 17 beta-estradiol (E2), 1 or 24 h prior to the administration of the carcinogen. The average size of the lesions was the same in the E2 pretreated and unpretreated animals. The number of gamma-glutamyltranspeptidase (GGT)-positive foci per cm3 of liver increased from 364 +/- 57 in unpretreated animals to 1149 +/- 186 in animals receiving E2 24 h before DENA; it raised to 3779 +/- 280 when the hormone was injected 1 h before the carcinogen, i.e. about 25% of the number of foci scored in rats receiving the carcinogen 24 h after partial hepatectomy. The hypothesis is proposed that 1-h pretreatment with E2 increases hepatocyte susceptibility towards DENA action by enhancing the accessibility of the genome to the carcinogen.
G Taton, and
P Servais, and
P Galand
March 1987,
Japanese journal of cancer research : Gann,
G Taton, and
P Servais, and
P Galand
June 1988,
Japanese journal of cancer research : Gann,
G Taton, and
P Servais, and
P Galand
April 1989,
Cancer letters,
G Taton, and
P Servais, and
P Galand
July 1994,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
G Taton, and
P Servais, and
P Galand
August 1992,
Carcinogenesis,
G Taton, and
P Servais, and
P Galand
September 2002,
Cell biochemistry and function,
G Taton, and
P Servais, and
P Galand
January 1984,
Eksperimental'naia onkologiia,
G Taton, and
P Servais, and
P Galand
October 1989,
Carcinogenesis,
G Taton, and
P Servais, and
P Galand
December 1989,
Tumori,
G Taton, and
P Servais, and
P Galand
November 1988,
Carcinogenesis,
