Effects of 780-nm low-level laser therapy with a pulsed gallium aluminum arsenide laser on the healing of a surgically induced open skin wound of rat. 2010

Mohammad Bayat, and Afsaneh Azari, and Mohammad Ghasem Golmohammadi
Physical Therapy Research Group, Academic Center for Education, Culture, and Research, Iran Medical Science Branch University, Vanak, Tehran, Iran. bayat_m@yahoo.com

OBJECTIVE The aim of the present investigation is to evaluate the effects of a 780-nm low-level laser on open skin wound healing. BACKGROUND Optimal parameters of low-level laser therapy (LLLT) for wound healing are discussed. METHODS One full-thickness skin wound was surgically induced in the dorsum skin of 30 rats. The rats were divided into two groups. Rats in the experimental group were daily treated with a gallium aluminum arsenide (GaAlAs) laser (2 J/cm(2), lambda = 780 nm, pulse frequency of 2336 Hz). Rats in the sham-exposed group received LLLT with switched off equipment. After 4, 7, and 15 days, wounds were checked by histological and biomechanical methods. Data were analyzed by the Mann-Whitney U-test. RESULTS Fibroblasts, endothelium of blood vessels, blood vessel sections, and maximum stress were significantly increased, whereas macrophages were significantly decreased, compared with those of the sham-exposed group. CONCLUSIONS Pulsed LLLT with a 780-nm GaAlAs laser significantly accelerates the process of healing of surgically induced, full-thickness skin wounds in rat.

UI MeSH Term Description Entries
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D005347 Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. Fibroblast
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012867 Skin The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D054023 Lasers, Semiconductor Lasers with a semiconductor diode as the active medium. Diode lasers transform electric energy to light using the same principle as a light-emitting diode (LED), but with internal reflection capability, thus forming a resonator where a stimulated light can reflect back and forth, allowing only a certain wavelength to be emitted. The emission of a given device is determined by the active compound used (e.g., gallium arsenide crystals doped with aluminum or indium). Typical wavelengths are 810, 1,060 and 1,300 nm. (From UMDNS, 2005) Diode Lasers,Gallium Aluminum Arsenide Lasers,Gallium Arsenide Lasers,GaAlAs Lasers,GaAs Lasers,Lasers, GaAlAs,Lasers, GaAs,Lasers, Gallium Aluminum Arsenide,Lasers, Gallium Arsenide,Lasers, Quantum Cascade,Quantum Cascade Lasers,Semiconductor Diode Lasers,Arsenide Laser, Gallium,Arsenide Lasers, Gallium,Diode Laser,Diode Laser, Semiconductor,Diode Lasers, Semiconductor,GaAlAs Laser,GaAs Laser,Gallium Arsenide Laser,Laser, Diode,Laser, GaAlAs,Laser, GaAs,Laser, Gallium Arsenide,Laser, Quantum Cascade,Laser, Semiconductor,Laser, Semiconductor Diode,Lasers, Diode,Lasers, Semiconductor Diode,Quantum Cascade Laser,Semiconductor Diode Laser,Semiconductor Laser,Semiconductor Lasers
D062109 Dermatologic Surgical Procedures Operative procedures performed on the SKIN. Cutaneous Surgery,Cutaneous Surgical Procedures,Dermatologic Surgery,Skin Surgery,Cutaneous Surgeries,Cutaneous Surgical Procedure,Dermatologic Surgeries,Dermatologic Surgical Procedure,Procedure, Cutaneous Surgical,Procedure, Dermatologic Surgical,Procedures, Cutaneous Surgical,Procedures, Dermatologic Surgical,Skin Surgeries,Surgeries, Cutaneous,Surgeries, Dermatologic,Surgeries, Skin,Surgery, Cutaneous,Surgery, Dermatologic,Surgery, Skin,Surgical Procedure, Cutaneous,Surgical Procedure, Dermatologic,Surgical Procedures, Cutaneous,Surgical Procedures, Dermatologic
D028022 Low-Level Light Therapy Treatment using irradiation with light of low power intensity so that the effects are a response to the light and not due to heat. A variety of light sources, especially low-power lasers are used. LLLT,Laser Biostimulation,Laser Irradiation, Low-Power,Laser Therapy, Low-Level,Photobiomodulation,Laser Phototherapy,Laser Therapy, Low-Power,Low-Level Laser Therapy,Low-Power Laser Irradiation,Low-Power Laser Therapy,Photobiomodulation Therapy,Biostimulation, Laser,Irradiation, Low-Power Laser,Laser Irradiation, Low Power,Laser Therapies, Low-Level,Laser Therapies, Low-Power,Laser Therapy, Low Level,Laser Therapy, Low Power,Light Therapies, Low-Level,Light Therapy, Low-Level,Low Level Laser Therapy,Low Level Light Therapy,Low Power Laser Irradiation,Low Power Laser Therapy,Low-Level Laser Therapies,Low-Level Light Therapies,Low-Power Laser Therapies,Photobiomodulation Therapies,Photobiomodulations,Phototherapy, Laser,Therapies, Low-Level Light,Therapies, Photobiomodulation,Therapy, Low-Level Light,Therapy, Photobiomodulation

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