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The effect of simultaneous pretreatment with vitamins C and E on the toxicity and mutagenicity of K2Cr2O7 in rats and guinea pigs was evaluated. Dietary pretreatment of Cr(VI)-intoxicated rats with ascorbic acid or alpha-tocopherol normalized vitamin C levels in lungs but not in kidneys. The synergistic preventive effect of both vitamins was confirmed in the production of lipoperoxides in Cr(VI)-intoxicated rats. Simultaneous administration of vitamins C and E in guinea pigs prevented the decrease of vitamin C levels provoked by the oxidative effects of Cr(VI). The results of the micronucleus test in bone marrow showed that it was vitamin C that caused the antimutagenic effect against bichromate, in both rats and guinea pigs. The effect of vitamin E was demonstrated only in an increase of the ratio of NCE to PCE, i.e., in a decrease of the cytotoxic but not the mutagenic effects of hexavalent chromium.
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
April 1977,
Applied and environmental microbiology,
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
January 1982,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
August 2008,
Inflammopharmacology,
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
October 1978,
Mutation research,
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
June 2007,
Critical reviews in toxicology,
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
January 1990,
Reproductive toxicology (Elmsford, N.Y.),
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
December 2007,
Alcohol (Fayetteville, N.Y.),
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
May 1997,
Toxicology letters,
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
January 1990,
Food additives and contaminants,
D Chorvatovicová, and
E Ginter, and
A Kosinová, and
Z Zloch
March 2000,
TreatmentUpdate,
