Biomaterial Database

Some historical aspects of understanding placental development, structure and function. 2010

Lawrence D Longo, and Lawrence P Reynolds

Center for Perinatal Biology, Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, California, USA. llongo@llu.edu

Ideas concerning the placenta, its development, structure and function can be traced to antiquity. An issue of importance that was only resolved in the late-eighteenth to early-nineteenth century is that of the separate nature of the maternal and fetal placental circulations. Other vital issues include the placentas of twins, the structure of placental villi and their covering, the classification of placental types, the existence of the intervillous space, and the relation of maternal to fetal blood flows in the placenta. Contemporary challenges in placental biology include understanding the basic mechanisms of numerous aspects of metabolism, endocrinology, immunology, epigenetics, and the role of specific placental proteins in embryonic/fetal development.

UI	MeSH Term	Description	Entries
D010920	Placenta	A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).	Placentoma, Normal,Placentome,Placentas,Placentomes
D010929	Placentation	The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.	Hemochorial Placental Development,Hemochorial Placentation,Placental Development,Placental Development, Hemochorial,Placentation, Hemochorial
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015509	Developmental Biology	The field of BIOLOGY which deals with the process of the GROWTH AND DEVELOPMENT of an organism.	Auxology,Biology, Developmental
D049668	History, 15th Century	Time period from 1401 through 1500 of the common era.	15th Century History,15th Cent. History (Medicine),15th Cent. History of Medicine,15th Cent. Medicine,Historical Events, 15th Century,History of Medicine, 15th Cent.,History, Fifteenth Century,Medical History, 15th Cent.,Medicine, 15th Cent.,15th Cent. Histories (Medicine),15th Century Histories,Cent. Histories, 15th (Medicine),Cent. History, 15th (Medicine),Century Histories, 15th,Century Histories, Fifteenth,Century History, 15th,Century History, Fifteenth,Fifteenth Century Histories,Fifteenth Century History,Histories, 15th Cent. (Medicine),Histories, 15th Century,Histories, Fifteenth Century,History, 15th Cent. (Medicine)
D049669	History, 16th Century	Time period from 1501 through 1600 of the common era.	16th Century History,16th Cent. History (Medicine),16th Cent. History of Medicine,16th Cent. Medicine,Historical Events, 16th Century,History of Medicine, 16th Cent.,History, Sixteenth Century,Medical History, 16th Cent.,Medicine, 16th Cent.,16th Cent. Histories (Medicine),16th Century Histories,Cent. Histories, 16th (Medicine),Cent. History, 16th (Medicine),Century Histories, 16th,Century Histories, Sixteenth,Century History, 16th,Century History, Sixteenth,Histories, 16th Cent. (Medicine),Histories, 16th Century,Histories, Sixteenth Century,History, 16th Cent. (Medicine),Sixteenth Century Histories,Sixteenth Century History
D049670	History, 17th Century	Time period from 1601 through 1700 of the common era.	17th Century History,17th Cent. History (Medicine),17th Cent. History of Medicine,17th Cent. Medicine,Historical Events, 17th Century,History of Medicine, 17th Cent.,History, Seventeenth Century,Medical History, 17th Cent.,Medicine, 17th Cent.,17th Cent. Histories (Medicine),17th Century Histories,Cent. Histories, 17th (Medicine),Century Histories, Seventeenth,Century History, 17th,Century History, Seventeenth,Histories, 17th Cent. (Medicine),Histories, 17th Century,Histories, Seventeenth Century,History, 17th Cent. (Medicine),Seventeenth Century Histories,Seventeenth Century History
D049671	History, 18th Century	Time period from 1701 through 1800 of the common era.	18th Century History,18th Cent. History (Medicine),18th Cent. History of Medicine,18th Cent. Medicine,Historical Events, 18th Century,History of Medicine, 18th Cent.,History, Eighteenth Century,Medical History, 18th Cent.,Medicine, 18th Cent.,18th Century Histories,Cent. History, 18th (Medicine),Cent. Medicine, 18th,Century Histories, 18th,Century Histories, Eighteenth,Century History, 18th,Century History, Eighteenth,Eighteenth Century Histories,Eighteenth Century History,Histories, 18th Century,Histories, Eighteenth Century,History, 18th Cent. (Medicine)