Biomaterial Database

Inhibition of skin graft rejection in mice by rapamycin: a novel immunosuppressive macrolide. 1991

C P Eng, and J Gullo-Brown, and J Y Chang, and S N Sehgal

Department of Immunopharmacology, Wyeth-Ayerst Research, Princeton, NJ 08543.

UI	MeSH Term	Description	Entries
D007166	Immunosuppressive Agents	Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.	Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D008297	Male		Males
D008807	Mice, Inbred BALB C	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008809	Mice, Inbred C3H	An inbred strain of mouse that is used as a general purpose strain in a wide variety of RESEARCH areas including CANCER; INFECTIOUS DISEASES; sensorineural, and cardiovascular biology research.	Mice, C3H,Mouse, C3H,Mouse, Inbred C3H,C3H Mice,C3H Mice, Inbred,C3H Mouse,C3H Mouse, Inbred,Inbred C3H Mice,Inbred C3H Mouse
D008811	Mice, Inbred DBA	An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS.	Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D011090	Polyenes	Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES.	Cumulenes
D003524	Cyclosporins	A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.	Cyclosporines
D006084	Graft Rejection	An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.	Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections
D006085	Graft Survival	The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.	Graft Survivals,Survival, Graft,Survivals, Graft
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia

Related Publications

C P Eng, and J Gullo-Brown, and J Y Chang, and S N Sehgal

Rapamycin: a novel immunosuppressive macrolide.

January 1994, Medicinal research reviews,

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Rapamycin: in vitro profile of a new immunosuppressive macrolide.

June 1993, Annals of the New York Academy of Sciences,

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Clearing of psoriasis by a novel immunosuppressive macrolide.

April 1996, The Journal of investigative dermatology,

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Skin graft rejection by beta 2-microglobulin-deficient mice.

April 1992, The Journal of experimental medicine,

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Studies of leukergy in skin graft rejection in mice.

January 1973, Folia biologica,

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[Effect of Tripterygium wolfordii on inhibition of rejection reaction of allogeneic skin graft in mice].

July 1995, Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns,

C P Eng, and J Gullo-Brown, and J Y Chang, and S N Sehgal

[Rapamycin: a new immunosuppressive agent capable of inhibiting chronic rejection?].

January 2001, Casopis lekaru ceskych,

C P Eng, and J Gullo-Brown, and J Y Chang, and S N Sehgal

Skin graft rejection after allogeneic tooth transplants in mice.

January 1984, Journal of dental research,

C P Eng, and J Gullo-Brown, and J Y Chang, and S N Sehgal

Gal mismatch alone causes skin graft rejection in mice.

September 2002, Transplantation,

C P Eng, and J Gullo-Brown, and J Y Chang, and S N Sehgal

Cimetidine does not accelerate skin graft rejection in mice.

April 1980, Clinical and experimental immunology,