BIOMAT Database Logo BIOMAT Database Logo

Rapamycin: a novel immunosuppressive macrolide. 1994

S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Wyeth-Ayerst Research, Princeton, New Jersey 08543.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D011090 Polyenes Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES. Cumulenes
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001327 Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. Autoimmune Disease,Disease, Autoimmune,Diseases, Autoimmune
D016377 Organ Transplantation Transference of an organ between individuals of the same species or between individuals of different species. Grafting, Organ,Transplantation, Organ,Graftings, Organ,Organ Grafting,Organ Graftings,Organ Transplantations,Transplantations, Organ
D020123 Sirolimus A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. Rapamycin,AY 22-989,I-2190A,Rapamune,AY 22 989,AY 22989,I 2190A,I2190A

Related Publications

S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Inhibition of skin graft rejection in mice by rapamycin: a novel immunosuppressive macrolide.
February 1991, Transplantation proceedings,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Rapamycin: in vitro profile of a new immunosuppressive macrolide.
June 1993, Annals of the New York Academy of Sciences,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Clearing of psoriasis by a novel immunosuppressive macrolide.
April 1996, The Journal of investigative dermatology,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Immunosuppressive profile of rapamycin.
November 1993, Annals of the New York Academy of Sciences,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Pharmacology of rapamycin: a new immunosuppressive agent.
January 1991, British journal of rheumatology,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin.
December 1998, Journal of chromatography. B, Biomedical sciences and applications,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.
June 1998, Current opinion in immunology,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Therapeutic monitoring of rapamycin: a new immunosuppressive drug.
December 1993, Therapeutic drug monitoring,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
RAD, a new immunosuppressive macrolide in murine corneal transplantation.
September 2001, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
S N Sehgal, and K Molnar-Kimber, and T D Ocain, and B M Weichman
Preclinical evaluation of a new potent immunosuppressive agent, rapamycin.
August 1991, Transplantation,
Copied contents to your clipboard!