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After total-body exposure to various doses of ionizing radiation, the ability of lymphocytes to interact specifically with high endothelial venules of rat cervical and mesenteric lymph nodes was analyzed in frozen sections. Following a radiation dose of 1.5 Gy, high endothelial venules remained intact and the binding of unirradiated lymphocytes to the venules was enhanced relative to unirradiated controls. At radiation doses above 5.0 Gy, damage to high endothelial venules was observed histologically as well as assessed functionally. There was a significant decrease in specific lymphocyte-venule binding and a significant increase in nonspecific binding. These findings suggest that radiation-induced damage to high endothelial venules might play a role in radiation-induced immunosuppression by interfering with the normal passage of lymphocytes from the blood into lymph nodes via a specific interaction between lymphocytes and high endothelial venules.
M L Hale, and
R Briggs, and
K F McCarthy
March 2013,
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M L Hale, and
R Briggs, and
K F McCarthy
November 1976,
Immunology,
M L Hale, and
R Briggs, and
K F McCarthy
August 2001,
Blood,
M L Hale, and
R Briggs, and
K F McCarthy
May 2004,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M L Hale, and
R Briggs, and
K F McCarthy
April 2013,
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M L Hale, and
R Briggs, and
K F McCarthy
June 2010,
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M L Hale, and
R Briggs, and
K F McCarthy
May 1997,
Biochemical Society transactions,
M L Hale, and
R Briggs, and
K F McCarthy
September 2005,
Lymphology,
M L Hale, and
R Briggs, and
K F McCarthy
March 1975,
The Anatomical record,
M L Hale, and
R Briggs, and
K F McCarthy
December 1983,
The Anatomical record,
