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Murine mammary tumor virus main glycoprotein (gp47), prepared by diethylaminoethyl cellulose and hydroxyapatite chromatography of detergent-mercaptoethanol-KCI-disrupted virion, was used as labeled antigen in a highly specific and reproducible radioimmunoassay. Seven other (glyco) proteins of the virus were antigenically distinct from gp47. Serum and organs of unifected C57BL mice did not contain gp47, but sera of infected Swiss and RIII mice did contain the antigen. Despite the high content in the mammary gland, the level of gp47 in other organs was identical in male and female mice. The titer of gp47 in serum was high in tumor-bearing females, but it varied with the mouse strain. Anti-gp47 immunoglobulins could not be detected. The investigation included 314 human sera (107 normal, 65 benign mastopathy, 89 breast vancer, and 53 digestive cancer). None contained an antigen related to gp47. One of 20 human mammary cyst fluids was positive.
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
June 1978,
Cancer research,
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
February 1982,
Indian journal of experimental biology,
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
August 1982,
Journal of immunology (Baltimore, Md. : 1950),
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
November 1977,
Journal of the National Cancer Institute,
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
February 1983,
Cancer,
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
April 1972,
Journal of the National Cancer Institute,
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
March 1980,
Cancer research,
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
August 1978,
Journal of the National Cancer Institute,
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
November 1973,
International journal of cancer,
P F Zangerie, and
C M Calberg-Bacq, and
C Colin, and
P Franchimont, and
C François, and
L Gosselin, and
S Kozma, and
P M Osterrieth
June 1978,
Virology,
