-transparent.png){kind=logo}
The effects of anti-rheumatic drugs (lobenzarit (CCA); 10 and 50mg/kg, cyclophosphamide (CP); 5 mg/kg and dexamethasone (DM); 0.25mg/kg) were evaluated immunologically and histopathologically on DBA/1J mice that develop polyarthritis after immunization by the intradermal injection of type II collagen. Serum anti-type II collagen IgG levels in the groups treated with CP and DM were significantly suppressed to 1/2 and 1/10 as compared to those of the positive control group, respectively. Those of both groups treated with CCA were not different from those of the positive control group. Histopathological examination revealed that treatment with CP and DM markedly reduced or suppressed inflammatory changes and resulted in low incidence of arthritis. From the standpoint mentioned above, treatment with anti-rheumatic drugs suppressed the development of arthritis in this model, and we could confirm that this model was useful for evaluation of the effect of anti-rheumatic drugs.
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
October 1997,
Experimental animals,
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
April 1997,
Experimental animals,
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
August 2002,
Journal of immunology (Baltimore, Md. : 1950),
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
January 2007,
Journal of applied toxicology : JAT,
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
January 2002,
Journal of cellular and molecular medicine,
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
January 2004,
Biological & pharmaceutical bulletin,
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
September 2003,
Biochemical pharmacology,
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
March 1996,
Clinical and experimental pharmacology & physiology,
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
January 1994,
International journal of tissue reactions,
K Imaizumi, and
H Hinoue, and
M Ueno, and
I Takata, and
T Sato, and
Y Minato, and
M Takeshita, and
A Okaniwa
January 2005,
Clinical and experimental rheumatology,
