BIOMAT Database Logo BIOMAT Database Logo

Effects of cytogenin, a novel anti-arthritic agent, on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats. 1994

S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Central Research Laboratories, Mercian Corporation, Fujisawa, Japan.

The anti-arthritic effects of cytogenin (8-hydroxy-3-hydroxymethyl-6- methoxyisocoumarin) on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats were examined. Prophylactic treatment with cytogenin (30, 100 mg/kg) had a potent inhibitory effect on type II collagen-induced arthritis. Prophylactic or therapeutic treatment with cytogenin (10, 30 and 100 mg/kg) also had a potent inhibitory effect on adjuvant arthritis. In contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), cytogenin (10, 30 and 100 mg/kg) had neither an anti-inflammatory effect on carrageenan-induced paw oedema in rats nor an analgesic effect on acetic acid-induced writhing in mice. These results suggest that the mode of the anti-arthritic action of cytogenin is different from that of NSAIDs and that cytogenin may become a useful drug for the treatment of rheumatoid arthritis.

UI MeSH Term Description Entries
D008297 Male Males
D008811 Mice, Inbred DBA An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D011917 Rats, Inbred Lew An inbred strain of rat that is used in BIOMEDICAL RESEARCH. Rats, Inbred Lewis,Rats, Lew,Inbred Lew Rat,Inbred Lew Rats,Inbred Lewis Rats,Lew Rat,Lew Rat, Inbred,Lew Rats,Lew Rats, Inbred,Lewis Rats, Inbred,Rat, Inbred Lew,Rat, Lew
D002351 Carrageenan A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES. Carrageenin,iota-Carrageenan,kappa-Carrageenan,lambda-Carrageenan,iota Carrageenan,kappa Carrageenan,lambda Carrageenan
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D003374 Coumarins Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid. 1,2-Benzopyrone Derivatives,1,2-Benzopyrones,Coumarin Derivative,Coumarine,1,2-Benzo-Pyrones,Benzopyran-2-ones,Coumarin Derivatives,Coumarines,1,2 Benzo Pyrones,1,2 Benzopyrone Derivatives,1,2 Benzopyrones,Benzopyran 2 ones,Derivative, Coumarin,Derivatives, 1,2-Benzopyrone,Derivatives, Coumarin
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000894 Anti-Inflammatory Agents, Non-Steroidal Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Analgesics, Anti-Inflammatory,Aspirin-Like Agent,Aspirin-Like Agents,NSAID,Non-Steroidal Anti-Inflammatory Agent,Non-Steroidal Anti-Inflammatory Agents,Nonsteroidal Anti-Inflammatory Agent,Anti Inflammatory Agents, Nonsteroidal,Antiinflammatory Agents, Non Steroidal,Antiinflammatory Agents, Nonsteroidal,NSAIDs,Nonsteroidal Anti-Inflammatory Agents,Agent, Aspirin-Like,Agent, Non-Steroidal Anti-Inflammatory,Agent, Nonsteroidal Anti-Inflammatory,Anti-Inflammatory Agent, Non-Steroidal,Anti-Inflammatory Agent, Nonsteroidal,Anti-Inflammatory Analgesics,Aspirin Like Agent,Aspirin Like Agents,Non Steroidal Anti Inflammatory Agent,Non Steroidal Anti Inflammatory Agents,Nonsteroidal Anti Inflammatory Agent,Nonsteroidal Anti Inflammatory Agents,Nonsteroidal Antiinflammatory Agents

Related Publications

S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Effects of alpha-linked galactooligosaccharide on adjuvant-induced arthritis in Wistar rats and type II collagen-induced arthritis in DBA/1J mice.
January 2004, International journal of tissue reactions,
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Immunohistochemical study on type II collagen-induced arthritis in DBA/1J mice.
October 1997, Experimental animals,
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Streptococcus sanguis modulates type II collagen-induced arthritis in DBA/1J mice.
August 2002, Journal of immunology (Baltimore, Md. : 1950),
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Oxidative status of DBA/1J mice with type II collagen-induced arthritis.
January 2007, Journal of applied toxicology : JAT,
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice.
January 2004, Biological & pharmaceutical bulletin,
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Suppressive effects of a herbal formula, TBL-1, on type II collagen-induced arthritis in DBA/1J mice.
March 1996, Clinical and experimental pharmacology & physiology,
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Pathological evaluation of anti-rheumatic drugs on type II collagen-induced arthritis in DBA/1J mouse.
January 1991, Jikken dobutsu. Experimental animals,
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice.
February 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats.
December 2018, Pharmaceutical biology,
S Hirano, and K Wakazono, and N Agata, and T Mase, and R Yamamoto, and M Matsufuji, and N Sakata, and H Iguchi, and H Tone, and M Ishizuka
Expression of survivin in synovium and cartilage in DBA/1J mice with type II collagen-induced arthritis.
January 2005, Clinical and experimental rheumatology,
Copied contents to your clipboard!