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1. The effect of extracellular volume expansion (ECVE) on renal production of cyclic AMP was evaluated in 19 thyroparathyroidectomized dogs. ECVE was produced by the infusion of Ringer bicarbonate solution at a rate of 2 ml min-1 kg-1 body weight; cyclic AMP was measured in plasma obtained from the aorta and renal vein and in the urine. 2. During the natriuresis of ECVE urinary excretion of cyclic AMP, the clearance of cyclic AMP, net nephrogenous cyclic AMP added both to urine and to the renal vein and hence total nephrogenous cyclic AMP increased significantly. 3. This rise in net production of cyclic AMP and a significant natriuresis by the kidney persisted for 60--90 min after discontinuation of active ECVE and return of renal plasma flow to normal. 4. The results support the notion that an increase in the production of cyclic AMP by the kidney may play a role in the natriuresis of ECVE.
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
April 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
August 1974,
The Journal of clinical endocrinology and metabolism,
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
January 1976,
Endocrinologia experimentalis,
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
January 1976,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
July 2003,
The Journal of surgical research,
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
September 1973,
Investigative urology,
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
January 1980,
Nephron,
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
January 1980,
Advances in experimental medicine and biology,
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
April 1973,
Kidney international,
R M Friedler, and
C Descoeudres, and
K Kurokawa, and
W J Kreusser, and
S G Massry
December 1977,
Revista brasileira de pesquisas medicas e biologicas,
