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Three days after creating an access to the turcica on the sphenoid bone, twelve anesthetized mongrel dogs, after control collections, were submitted to extracellular volume expansion with saline. Thereafter, maintained constant the rate of saline infusion, the dura-mater covering the pituitary gland was incised in all dogs, the hypohysis being removed in seven and remaining untouched in the other five dogs. Pharmacological doses of pitressin, glycocorticoids and mineralocorticoids were administered to all dogs. It was shown, for the same filtered sodium load(p is greater than 0.05), that hypophysectomy produces a significant reduction (p is less than 0.05) in urinary sodium excretion previously elevated by the extracellular volume expansion, while durostomy only, without removal of th hypophysis, did not change (p is greater than 0.05) the rate of sodium excretion. Thus, the pituitary gland could be considered as contributing to natriuresis during extracellular volume expansion, all other factors related to this expansion remaining constant in both, hypophysectomized and sham operated dogs.
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
January 1976,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
December 1977,
Clinical science and molecular medicine,
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
January 1968,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
July 2003,
The Journal of surgical research,
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
November 1975,
Experientia,
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
June 1969,
Clinical science,
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
April 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
April 1977,
Journal of applied physiology: respiratory, environmental and exercise physiology,
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
September 1973,
Investigative urology,
D Korn, and
M M Machado, and
U Andrade, and
J P Cipullo, and
H Ajzen, and
O L Ramos
January 1980,
Advances in experimental medicine and biology,
