-transparent.png){kind=logo}
Exposure to inescapable footshock provoked region-specific alterations of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) activity across six strains of mice (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, DBA/2J and CD-1). The stressor provoked reductions of hypothalamic NE and increased MHPG accumulation in all strains. In contrast, the effects of the stressor on NE activity in the hippocampus and locus coeruleus varied appreciably across strains. In the mesocortex and nucleus accumbens shock induced an increase of DOPAC accumulation and pronounced reductions of DA in some strains, while in others these variations were less pronounced or entirely absent. Stressor-provoked alterations of 5-HT and 5-HIAA were most evident in the mesocortex. Strain-specific neurochemical alterations following footshock are discussed relative to stressor-induced behavioral disturbances and animal models of depression.
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
September 1994,
Pharmacology, biochemistry, and behavior,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
July 1994,
Behavioural brain research,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
February 2001,
Brain research,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
September 1964,
Nature,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
May 1971,
Diseases of the nervous system,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
August 2007,
Behavioural brain research,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
June 1989,
Brain, behavior, and immunity,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
January 1997,
Neurotoxicology and teratology,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
January 2000,
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques,
N Shanks, and
S Zalcman, and
R M Zacharko, and
H Anisman
January 1985,
Bioelectromagnetics,
