Biomaterial Database

The effects of food schedule adaptation on the ability of naloxone to suppress the acquisition of schedule-induced polydipsia. 1991

B Geter, and M A Kautz, and C L Wetherington, and A L Riley

Department of Psychology, American University, Washington, DC 20016.

Naloxone suppressed the acquisition of schedule-induced polydipsia (SIP) in rats given no previous exposure to the feeding schedule. Adaptation to the feeding schedule prior to SIP acquisition attenuated this suppression. Specifically, water consumption, bout probability, licks/bout and maximum lick rates during the interpellet interval (IPI) were significantly increased by adaptation. Although adaptation attenuated the suppressive effects of naloxone on SIP, this attenuation was not complete. Adapted, naloxone-treated subjects displayed both decreased water consumption and bout probability as compared to distilled water-treated controls. Unlike the effects of adaptation on naloxone's suppression of SIP, adaptation completely eliminated naloxone's suppression of feeding. That adapted subjects ate at control levels while still displaying a lower level of SIP suggests that the suppressive effect of naloxone on the acquisition of SIP is not an indirect effect of naloxone on feeding, but rather a direct effect of naloxone on developing SIP. Given that naloxone has a general suppressive effect on drinking (including SIP), what remains to be determined is why naloxone has no effect on established SIP. Possible explanations for this are discussed.

UI	MeSH Term	Description	Entries
D009270	Naloxone	A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.	MRZ 2593-Br,MRZ-2593,Nalone,Naloxon Curamed,Naloxon-Ratiopharm,Naloxone Abello,Naloxone Hydrobromide,Naloxone Hydrochloride,Naloxone Hydrochloride Dihydride,Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Narcan,Narcanti,Abello, Naloxone,Curamed, Naloxon,Dihydride, Naloxone Hydrochloride,Hydrobromide, Naloxone,Hydrochloride Dihydride, Naloxone,Hydrochloride, Naloxone,MRZ 2593,MRZ 2593 Br,MRZ 2593Br,MRZ2593,Naloxon Ratiopharm
D012055	Reinforcement Schedule	A schedule prescribing when the subject is to be reinforced or rewarded in terms of temporal interval in psychological experiments. The schedule may be continuous or intermittent.	Reinforcement Schedules,Schedule, Reinforcement,Schedules, Reinforcement
D003216	Conditioning, Operant	Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.	Instrumental Learning,Learning, Instrumental,Operant Conditioning,Conditionings, Operant,Instrumental Learnings,Learnings, Instrumental,Operant Conditionings
D004327	Drinking Behavior	Behaviors associated with the ingesting of water and other liquids; includes rhythmic patterns of drinking (time intervals - onset and duration), frequency and satiety.	Behavior, Drinking,Behaviors, Drinking,Drinking Behaviors
D005247	Feeding Behavior	Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals.	Dietary Habits,Eating Behavior,Faith-based Dietary Restrictions,Feeding Patterns,Feeding-Related Behavior,Food Habits,Diet Habits,Eating Habits,Behavior, Eating,Behavior, Feeding,Behavior, Feeding-Related,Behaviors, Eating,Behaviors, Feeding,Behaviors, Feeding-Related,Diet Habit,Dietary Habit,Dietary Restriction, Faith-based,Dietary Restrictions, Faith-based,Eating Behaviors,Eating Habit,Faith based Dietary Restrictions,Faith-based Dietary Restriction,Feeding Behaviors,Feeding Pattern,Feeding Related Behavior,Feeding-Related Behaviors,Food Habit,Habit, Diet,Habit, Dietary,Habit, Eating,Habit, Food,Habits, Diet,Pattern, Feeding,Patterns, Feeding,Restrictions, Faith-based Dietary
D005260	Female		Females
D005502	Food	Substances taken in by the body to provide nourishment.	Foods
D000223	Adaptation, Psychological	A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed).	Behavior, Adaptive,Healthy Adaptation,Positive Adaptation,Psychological Recovery,Adaptation, Psychologic,Adjustment,Psychological Adaptation,Adaptation, Healthy,Adaptation, Positive,Adaptive Behavior,Adaptive Behaviors,Healthy Adaptations,Positive Adaptations,Psychologic Adaptation,Psychological Recoveries,Recovery, Psychological
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus