BIOMAT Database Logo BIOMAT Database Logo

Two new homoisoflavonoids from the fibrous roots of Ophiopogon japonicus (Thunb.) Ker-Gawl. 2009

Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. changlingd2010@yahoo.com.cn

Two new homoisoflavonoids ophiopogonone D (1) and ophiopogonanone G (2) were isolated from the fibrous roots of Ophiopogon japonicus. The structures of these two compounds were determined on the basis of spectroscopic means including HR-ESI-MS, 1D, and 2D NMR experiments. The cytotoxic activities of 1 and 2 against Hela and Hep2 cells are described.

UI MeSH Term Description Entries
D007529 Isoflavones 3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position. 3-Benzylchroman-4-One,3-Benzylidene-4-Chromanone,Homoisoflavone,Homoisoflavones,Isoflavone,Isoflavone Derivative,3-Benzylchroman-4-Ones,3-Benzylidene-4-Chromanones,Isoflavone Derivatives,3 Benzylchroman 4 One,3 Benzylchroman 4 Ones,3 Benzylidene 4 Chromanone,3 Benzylidene 4 Chromanones,Derivative, Isoflavone,Derivatives, Isoflavone
D004354 Drug Screening Assays, Antitumor Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals. Anticancer Drug Sensitivity Tests,Antitumor Drug Screens,Cancer Drug Tests,Drug Screening Tests, Tumor-Specific,Dye Exclusion Assays, Antitumor,Anti-Cancer Drug Screens,Antitumor Drug Screening Assays,Tumor-Specific Drug Screening Tests,Anti Cancer Drug Screens,Anti-Cancer Drug Screen,Antitumor Drug Screen,Cancer Drug Test,Drug Screen, Anti-Cancer,Drug Screen, Antitumor,Drug Screening Tests, Tumor Specific,Drug Screens, Anti-Cancer,Drug Screens, Antitumor,Drug Test, Cancer,Drug Tests, Cancer,Screen, Anti-Cancer Drug,Screen, Antitumor Drug,Screens, Anti-Cancer Drug,Screens, Antitumor Drug,Test, Cancer Drug,Tests, Cancer Drug,Tumor Specific Drug Screening Tests
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D006367 HeLa Cells The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. Cell, HeLa,Cells, HeLa,HeLa Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000972 Antineoplastic Agents, Phytogenic Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. Antineoplastics, Botanical,Antineoplastics, Phytogenic,Agents, Phytogenic Antineoplastic,Botanical Antineoplastics,Phytogenic Antineoplastic Agents,Phytogenic Antineoplastics
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D018517 Plant Roots The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990) Plant Bulbs,Plant Root,Bulb, Plant,Bulbs, Plant,Plant Bulb,Root, Plant,Roots, Plant
D019906 Nuclear Magnetic Resonance, Biomolecular NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope. Biomolecular Nuclear Magnetic Resonance,Heteronuclear Nuclear Magnetic Resonance,NMR Spectroscopy, Protein,NMR, Biomolecular,NMR, Heteronuclear,NMR, Multinuclear,Nuclear Magnetic Resonance, Heteronuclear,Protein NMR Spectroscopy,Biomolecular NMR,Heteronuclear NMR,Multinuclear NMR,NMR Spectroscopies, Protein,Protein NMR Spectroscopies,Spectroscopies, Protein NMR,Spectroscopy, Protein NMR
D031441 Ophiopogon A plant genus of the family Asparagaceae. Members contain steroidal glycosides and provide an ingredient of shengmaisan (DRUGS, CHINESE HERBAL). Mondo Grass,Ophiopogon japonicus,Ophiopogon maidon,Grass, Mondo,Grasses, Mondo,Mondo Grasses

Related Publications

Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
Two new furostanol glycosides from the fibrous root of Ophiopogon japonicus (Thunb.) Ker-Gawl.
September 2010, Journal of Asian natural products research,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl.
January 2011, Bioscience, biotechnology, and biochemistry,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
Three new neuritogenic steroidal saponins from Ophiopogon japonicus (Thunb.) Ker-Gawl.
December 2013, Steroids,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
Homoisoflavonoids from Ophiopogon japonicus Ker-Gawler.
April 2003, Phytochemistry,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
[Isolation and identification of homoisoflavanones from maidong (Ophiopogon japonicus (Thunb) Ker-Gawl)].
September 1987, Yao xue xue bao = Acta pharmaceutica Sinica,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
A novel steroidal glycoside, ophiofurospiside A from Ophiopogon japonicus (Thunb.) Ker-Gawl.
January 2008, Journal of Asian natural products research,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
[A study on the nutrient physiology of Ophiopogon japonicus (Thunb.) Ker-Gawl].
March 1998, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
Ophiopojaponin D, a new phenylpropanoid glycoside from Ophiopogon japonicus Ker-Gawl.
November 2005, Archives of pharmacal research,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
[Soil conditions for growth of Ophiopogon japonicus ker.-gawl].
April 1998, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Chang-Ling Duan, and Zhi-Yun Kang, and Cheng-Ren Lin, and Yong Jiang, and Jian-Xun Liu, and Peng-Fei Tu
Novel steroidal saponins with cytotoxic activities from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl.
January 2018, RSC advances,
Copied contents to your clipboard!