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New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl. 2011
Yuan Qu, and
Yang Zhang, and
Liang Pei, and
Yan Wang, and
Lijuan Gao, and
Qianming Huang, and
Makoto Ojika, and
Youji Sakagami, and
Jianhua Qi
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4' of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.
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