Corneal graft survival in HLA-A- and HLA-B-matched transplantations in high-risk cases with retrospective review of HLA-DR compatibility. 1991

W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
Cornea Service, Rotterdam Eye Hospital, The Netherlands.

In 107 HLA-A- and HLA-B-matched corneal transplantations performed in high-risk patients, the 3-year graft survival was 60.5%. The criteria used for the definition of high risk were vascularization of the recipient cornea and/or one or more previous failed grafts; they were also the indications for HLA typing and matching. Donor/recipient compatibility was defined by the presence of only 0 or 1 HLA-A or HLA-B mismatches. When non-immunological factors leading to graft failure were excluded, the 3-year survival was 76.3%. During that follow-up period, a total of 33 grafts failed; in 13 cases, the cause was allograft rejection. When only first transplants were considered, a 3-year graft survival of 81.0% was observed. Retrospective DR typing was possible in 33 cases. Because only three graft rejections occurred in that group, we were unable to assess the importance of DR compatibility on the survival of corneal allografts.

UI MeSH Term Description Entries
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006085 Graft Survival The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host. Graft Survivals,Survival, Graft,Survivals, Graft
D006650 Histocompatibility Testing Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed) Crossmatching, Tissue,HLA Typing,Tissue Typing,Crossmatchings, Tissue,HLA Typings,Histocompatibility Testings,Testing, Histocompatibility,Testings, Histocompatibility,Tissue Crossmatching,Tissue Crossmatchings,Tissue Typings,Typing, HLA,Typing, Tissue,Typings, HLA,Typings, Tissue
D006684 HLA-DR Antigens A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS. HLA-DR,Antigens, HLA-DR,HLA DR Antigens
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D014184 Transplantation, Homologous Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals. Transplantation, Allogeneic,Allogeneic Grafting,Allogeneic Transplantation,Allografting,Homografting,Homologous Transplantation,Grafting, Allogeneic
D015234 HLA-A Antigens Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts. Antigens, HLA-A,HLA-A,Antigens, HLA A,HLA A Antigens
D015235 HLA-B Antigens Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes. Antigens, HLA-B,HLA-B Antigen,HLA-B,Antigen, HLA-B,Antigens, HLA B,HLA B Antigen,HLA B Antigens

Related Publications

W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
September 1977, Documenta ophthalmologica. Advances in ophthalmology,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
January 1980, Scandinavian journal of urology and nephrology. Supplementum,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
December 1994, Transplantation proceedings,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
January 1986, Cornea,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
July 1986, The New England journal of medicine,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
January 1990, Clinical transplants,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
February 1995, Transplantation proceedings,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
February 1995, Transplantation proceedings,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
March 1979, Documenta ophthalmologica. Advances in ophthalmology,
W H Beekhuis, and G van Rij, and J G Renardel de Lavalette, and E Rinkel-van Driel, and G Persijn, and J D'Amaro
August 1994, The New England journal of medicine,
Copied contents to your clipboard!