Histamine antagonists; pyridil-N'benzyl-N-dimethyl-ethylenediamine (pyribenzamine) in symptomatic treatment of allergic manifestations.
1947
S M FEINBERG, and
S FRIEDLAENDER
UI
MeSH Term
Description
Entries
D005029
Ethylenediamines
Derivatives of ethylenediamine (the structural formula NH2CH2CH2NH2).
D006632
Histamine
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.