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A study was conducted to identify and characterise the toxic principle in Terminalia oblongata, commonly known as yellow-wood. Crude aqueous extracts of yellow-wood leaf were found to produce the same liver lesion in mice as has been reported in ruminants. The hepatotoxic fraction was isolated and identified as a hydrolysable vegetable tannin called punicalagin. When given orally, the dose required to produce toxicity was at least 20 times greater than when given intraperitoneally. Following a given dose of punicalagin, the onset and severity of liver necrosis was found to be related to the time interval after dosing. In addition to punicalagin, an unidentified nephrotoxic substance was found which was capable of producing avascular renal necrosis without liver necrosis.
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
October 1979,
Veterinary and human toxicology,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
June 1978,
Food and cosmetics toxicology,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
March 1986,
Bulletin of environmental contamination and toxicology,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
October 1977,
Toxicology and applied pharmacology,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
December 2020,
Journal of molecular neuroscience : MN,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
June 1993,
Australian veterinary journal,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
April 2001,
Toxicological sciences : an official journal of the Society of Toxicology,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
August 2005,
Archives of toxicology,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
October 2013,
Toxicology and industrial health,
L J Filippich, and
J Zhu, and
P Oelrichs, and
M T Alsalami, and
A J Doig, and
G R Cao, and
P B English
October 2019,
Molecular biology reports,
