Biomaterial Database

Modulated long-term potentiation in the cat superior cervical ganglion in vivo. 1991

F Alonso-deFlorida, and M A Morales, and A A Minzoni

Departamento de Biofísica y Biomatemáticas, U.N.A.M., México D.F.

In the sympathetic ganglion a high frequency conditioning train produces a post-train potentiation (PTrP) which decays with a temporal course that can be described by two components: an early faster component known as post-tetanic potentiation (PTP), and a long-lasting one which is known as long-term potentiation (LTP). The magnitude of PTP and LTP is thought to be a function of the subliminal fringe size. Moreover, under full activation of ganglion cells LTP does not appear due to the saturation conditions. LTP emerges only when the subliminal fringe is increased, and to achieve this, a low-level tetanization must be performed. However, another possibility, explored in this paper, is that in addition to the desaturation effect of the low-level conditions of tetanization, a different mechanism, responsible for the LTP appearance, may be introduced by these low-level conditions of tetanization. This possibility implies a variable LTP according to the input conditions; accordingly, the shape of LTP was compared in 4 experimental conditions in which the input to the ganglion cells was different; (1) supramaximal activation of the intact cervical sympathetic trunk (CST), (SPM); (2) submaximal activation of the intact CST, (SBM); (3) supramaximal activation of the partially transected CST, (TRN): and (4) supramaximal activation of the intact CST under partial nicotinic block with hexamethonium. (BLK). Even when PTrP was evoked with the same subliminal fringe obtained under the 3 low-level conditions of tetanization, the degree of potentiation and the proportion of PTP and LTP were different. After either SPM or SBM conditions LTP was negligible, though PTP developed to a certain degree.(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008564	Membrane Potentials	The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).	Resting Potentials,Transmembrane Potentials,Delta Psi,Resting Membrane Potential,Transmembrane Electrical Potential Difference,Transmembrane Potential Difference,Difference, Transmembrane Potential,Differences, Transmembrane Potential,Membrane Potential,Membrane Potential, Resting,Membrane Potentials, Resting,Potential Difference, Transmembrane,Potential Differences, Transmembrane,Potential, Membrane,Potential, Resting,Potential, Transmembrane,Potentials, Membrane,Potentials, Resting,Potentials, Transmembrane,Resting Membrane Potentials,Resting Potential,Transmembrane Potential,Transmembrane Potential Differences
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D005260	Female		Females
D005728	Ganglia, Sympathetic	Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.	Celiac Ganglia,Sympathetic Ganglia,Celiac Ganglion,Ganglion, Sympathetic,Ganglia, Celiac,Ganglion, Celiac,Sympathetic Ganglion
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013569	Synapses	Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.	Synapse