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Boldine, in low micromolar concentrations, was able to prevent brain homogenate autooxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation of lysozyme. These results are indicative of a high reactivity of boldine towards free radicals. The analysis of the boldine effect as a function of incubation times suggests that a metabolite resulting from the interaction of boldine with free radicals also exhibits antioxidant activity, being more efficient than boldine in brain homogenate auto-oxidation and less efficient in lysozyme protection experiments. This behavior may be accounted for in terms of the relative location of the scavengers needed to afford maximal protection.
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
March 1995,
Free radical biology & medicine,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
March 2007,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
February 1997,
Free radical research,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
January 1987,
Voprosy meditsinskoi khimii,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
November 1992,
Biochemical pharmacology,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
January 1998,
Proceedings of the Western Pharmacology Society,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
December 1998,
Pflugers Archiv : European journal of physiology,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
May 1995,
General pharmacology,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
January 2003,
Annals of clinical and laboratory science,
H Speisky, and
B K Cassels, and
E A Lissi, and
L A Videla
January 2007,
Ukrains'kyi biokhimichnyi zhurnal (1999 ),
