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Epinephrine injected intradermally activated pig skin adenylate cyclase and increased the epidermal cyclic AMP level in vivo. This biphasic response reached a maximum in 5 min and gradually decreased thereafter. The simultaneous injection of a cyclic AMP phosphodiesterase inhibitor, isobutyl methyl xanthin (IBMX) potentiated the increase. The simultaneous injection of a specific beta-adrenergic receptor inhibitor, propranolol, inhibited this accumulation of cyclic AMP. After the first activation by epinephrine in vivo, there was a marked refractoriness of the skin (epidermal) adenylate cyclase to subsequent epinephrine stimulation vivo and in vitro. This refractoriness was specific for catecholamine stimulation as responses to histamine were normal. Recovery from refractoriness started at 48 hr and was completed at 1 week after the injection of epinephrine.
H Iizuka, and
K Adachi, and
K M Halprin, and
V Levine
August 1976,
Biochemistry,
H Iizuka, and
K Adachi, and
K M Halprin, and
V Levine
December 1974,
Life sciences,
H Iizuka, and
K Adachi, and
K M Halprin, and
V Levine
December 1974,
Life sciences,
H Iizuka, and
K Adachi, and
K M Halprin, and
V Levine
December 1983,
The Journal of investigative dermatology,
H Iizuka, and
K Adachi, and
K M Halprin, and
V Levine
September 1984,
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H Iizuka, and
K Adachi, and
K M Halprin, and
V Levine
May 1976,
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H Iizuka, and
K Adachi, and
K M Halprin, and
V Levine
November 1977,
Biokhimiia (Moscow, Russia),
H Iizuka, and
K Adachi, and
K M Halprin, and
V Levine
January 1977,
Archives internationales de pharmacodynamie et de therapie,
H Iizuka, and
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V Levine
January 1974,
Endocrinology,
H Iizuka, and
K Adachi, and
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