Biomaterial Database

Seasonal effects of administration of melatonin and 5-methoxytryptophol on ovarian activity in the catfish Heteropneustes fossilis (Bloch). 1991

K P Joy, and A K Agha

Department of Zoology, Banaras Hindu University, Varanasi, India.

In Heteropneustes fossilis, effects of intraperitoneal administration (25 micrograms/fish, alternate days for a month 1 hr before the onset of dark phase) of melatonin (MEL) and 5-methoxytryptophol (5-MTL) on ovarian activity were investigated during different seasons of the annual reproductive cycle under natural photothermal conditions. The gonadosomatic index (GSI) had decreased significantly by MEL during preparatory and prespawning seasons, and by 5-MTL in all but the spawning season. Both MEL and 5-MTL administrations arrested vitellogenesis during the gonadal recrudescence phase. As a result, stage I previtellogenic oocytes showed a significant increase in the MEL group in the preparatory and prespawning seasons, and in the 5-MTL group only in the prespawning season. Almost the same trend was noticed in the percentage distribution of stage 2 and 3 oocytes. The percentage distribution of stage 4 postvitellogenic oocytes decreased significantly during the preparatory and prespawning seasons, but not in the spawning season. The indole treatment resulted in a highly significant increase in the percentage distribution of atretic oocytes during prespawning, spawning, and post-spawning phases. Total protein content of the ovary was significantly lower in all seasons after MEL treatment, and only in the preparatory and prespawning seasons following 5-MTL treatment. The ovarian glycogen level was significantly lower in the preparatory and prespawning seasons (MEL group), and in the 5-MTL group only in the prespawning phase. Ascorbic acid level was inhibited by the indole treatment in all seasons except in the 5-MTL group during the post-spawning season. The results show that both MEL and 5-MTL are effective in inhibiting ovarian vitellogenesis and inducing atresia in the catfish.

UI	MeSH Term	Description	Entries
D007211	Indoles	Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D007274	Injections, Intraperitoneal	Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.	Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D008550	Melatonin	A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
D009865	Oocytes	Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).	Ovocytes,Oocyte,Ovocyte
D010053	Ovary	The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.	Ovaries
D002397	Catfishes	Common name of the order Siluriformes. This order contains many families and over 2,000 species, including venomous species. Heteropneustes and Plotosus genera have dangerous stings and are aggressive. Most species are passive stingers.	Eremophilus mutisii,Heteropneustes,Plotosus,Siluriformes,Arius,Catfish,Colombian Catfish,Catfish, Colombian
D004334	Drug Administration Schedule	Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.	Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D005260	Female		Females
D005496	Follicular Atresia	The degeneration and resorption of an OVARIAN FOLLICLE before it reaches maturity and ruptures.	Atresia, Follicular,Atresias, Follicular,Follicular Atresias
D006003	Glycogen