Cyclic nucleotide-gated channels are involved in phototransduction of dermal photoreceptors in Lymnaea stagnalis. 2010

Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
Ecology, Evolution and Marine Biology, University of California Santa Barbara, Santa Barbara, CA 93106-6110, USA.

Dermal photoreceptors in the pond snail Lymnaea stagnalis mediate the whole-body withdrawal response, including pneumostome closure, elicited by a shadow passing over the pneumostome area. The pneumostome closure response is part of the defense reaction in Lymnaea. The shadow or 'light-off' stimulus elicits activity in a higher order interneuron, RPeD11, which has a major role in mediating defensive withdrawal behavior elicited by noxious or threatening stimuli. Here, we tested our hypothesis that cyclic nucleotide-gated (CNG) channels are involved in the dermal photoreceptor-mediated transduction of the shadow stimulus. The response to the shadow stimulus recorded in RPeD11 was abolished by 500 μM cis-diltiazem, which blocks cGMP-activated conductance of CNG channels. On the other hand, the shadow response elicited in RPeD11 was not blocked by 2-amino ethyldiphenyl borate (2-APB), a transient receptor potential (TRP) channel blocker. Consistent with the electrophysiologic data, cis-diltiazem blocked the shadow-evoked withdrawal response, whereas 2-APB did not block the withdrawal response evoked by the shadow stimulus in intact freely behaving Lymnaea. Together, these findings support the hypothesis that the second messenger in dermal photoreceptors involves CNG and not TRP channels.

UI MeSH Term Description Entries
D007395 Interneurons Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions. Intercalated Neurons,Intercalated Neuron,Interneuron,Neuron, Intercalated,Neurons, Intercalated
D008195 Lymnaea A genus of dextrally coiled freshwater snails that includes some species of importance as intermediate hosts of parasitic flukes. Lymnea,Lymnaeas,Lymneas
D010775 Photic Stimulation Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity. Stimulation, Photic,Visual Stimulation,Photic Stimulations,Stimulation, Visual,Stimulations, Photic,Stimulations, Visual,Visual Stimulations
D010786 Photoreceptor Cells Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade. Ciliary Photoreceptor Cells,Ciliary Photoreceptors,Rhabdomeric Photoreceptor Cells,Rhabdomeric Photoreceptors,Cell, Ciliary Photoreceptor,Cell, Photoreceptor,Cell, Rhabdomeric Photoreceptor,Cells, Ciliary Photoreceptor,Cells, Photoreceptor,Cells, Rhabdomeric Photoreceptor,Ciliary Photoreceptor,Ciliary Photoreceptor Cell,Photoreceptor Cell,Photoreceptor Cell, Ciliary,Photoreceptor Cell, Rhabdomeric,Photoreceptor Cells, Ciliary,Photoreceptor Cells, Rhabdomeric,Photoreceptor, Ciliary,Photoreceptor, Rhabdomeric,Photoreceptors, Ciliary,Photoreceptors, Rhabdomeric,Rhabdomeric Photoreceptor,Rhabdomeric Photoreceptor Cell
D001896 Boron Compounds Inorganic or organic compounds that contain boron as an integral part of the molecule. Borides,Compounds, Boron
D004110 Diltiazem A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions. Aldizem,CRD-401,Cardil,Cardizem,Dilacor,Dilacor XR,Dilren,Diltiazem Hydrochloride,Diltiazem Malate,Dilzem,Tiazac,CRD 401,CRD401
D006152 Cyclic GMP Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed) Guanosine Cyclic 3',5'-Monophosphate,Guanosine Cyclic 3,5 Monophosphate,Guanosine Cyclic Monophosphate,Guanosine Cyclic-3',5'-Monophosphate,3',5'-Monophosphate, Guanosine Cyclic,Cyclic 3',5'-Monophosphate, Guanosine,Cyclic Monophosphate, Guanosine,Cyclic-3',5'-Monophosphate, Guanosine,GMP, Cyclic,Guanosine Cyclic 3',5' Monophosphate,Monophosphate, Guanosine Cyclic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012879 Skin Physiological Phenomena The functions of the skin in the human and animal body. It includes the pigmentation of the skin. Skin Physiological Processes,Skin Physiology,Physiology, Skin,Skin Physiological Concepts,Skin Physiological Phenomenon,Skin Physiological Process,Concept, Skin Physiological,Concepts, Skin Physiological,Phenomena, Skin Physiological,Phenomenas, Skin Physiological,Phenomenon, Skin Physiological,Phenomenons, Skin Physiological,Physiological Concept, Skin,Physiological Concepts, Skin,Physiological Phenomena, Skin,Physiological Phenomenas, Skin,Physiological Phenomenon, Skin,Physiological Phenomenons, Skin,Process, Skin Physiological,Processes, Skin Physiological,Skin Physiological Concept,Skin Physiological Phenomenas,Skin Physiological Phenomenons
D054815 Cyclic Nucleotide-Gated Cation Channels A subgroup of cyclic nucleotide-regulated ION CHANNELS within the superfamily of pore-loop cation channels. They are expressed in OLFACTORY NERVE cilia and in PHOTORECEPTOR CELLS and some PLANTS. Cyclic-Nucleotide Gated Ion Channels,CNG Channel (Rod),Cationic Channel Protein (Rod),Cng Cation Channel,Cyclic Nucleotide-Gated Cation Channel,Cyclic-Nucleotide Gated Channel,Cation Channel, Cng,Channel, Cng Cation,Channel, Cyclic-Nucleotide Gated,Cyclic Nucleotide Gated Cation Channel,Cyclic Nucleotide Gated Cation Channels,Cyclic Nucleotide Gated Channel,Cyclic Nucleotide Gated Ion Channels,Gated Channel, Cyclic-Nucleotide

Related Publications

Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
January 2014, Biophysics (Nagoya-shi, Japan),
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
October 2006, The Journal of general physiology,
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
September 2001, The Journal of experimental biology,
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
April 1991, Trends in neurosciences,
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
October 2022, Trends in neurosciences,
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
January 1999, Advances in second messenger and phosphoprotein research,
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
January 2009, Handbook of experimental pharmacology,
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
June 1995, Current opinion in neurobiology,
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
September 2005, The European journal of neuroscience,
Sabrina Pankey, and Hiroshi Sunada, and Tetsuro Horikoshi, and Manabu Sakakibara
January 2003, Annual review of cell and developmental biology,
Copied contents to your clipboard!