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A rapid, sensitive, and specific enzyme immunometric assay for cyclosporine in whole blood has been developed for the aca analyzer, using a monoclonal antibody from Sandoz, Ltd. Between-run CVs ranged from 6.5 to 7.6% for samples containing between 60 and 400 ng/mL cyclosporine. Sensitivity was better than 25 ng/mL in the assay, which has an effective upper range of greater than 600 ng/mL. Two correlation studies compared cyclosporine values from the Du Pont method to those determined by HPLC procedures in three hospital laboratories. The results from a total of 120 whole blood samples with CsA between 20 and 800 ng/mL showed excellent correlation between the methodologies. HPLC and Du Pont CsA values from 10 day serial studies also correlated well for samples from a kidney, kidney-pancreas, heart, and two liver transplant patients. We conclude that the Du Pont CSA assay provides accurate and reproducible results in a convenient format in less than 30 minutes.
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
October 1983,
Seminars in thrombosis and hemostasis,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
November 1984,
Clinical chemistry,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
February 1984,
American journal of clinical pathology,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
June 1974,
Clinical chemistry,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
April 1983,
Clinical chemistry,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
January 1986,
Clinical chemistry,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
April 1983,
Clinical chemistry,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
March 1978,
Clinical chemistry,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
January 1979,
Clinical chemistry,
J B Hansen, and
H P Lau, and
C J Janes, and
W K Miller, and
D A Wiebe
January 1985,
Therapeutic drug monitoring,
