-transparent.png){kind=logo}
We describe an automated assay for digoxin that requires a 200-microL sample of serum. Total analysis time is 18 min. The method is extremely precise, with within-run CVs of 2.6, 1.6, and 4.9%, respectively, at 0.5, 1.5, and 3.5 micrograms of digoxin per liter (n = 20). The lower limit of detection is 0.2 micrograms of digoxin per liter. For patients' samples, the correlation with RIA (x) is excellent (r = 0.95; y = 0.95x - 0.14; standard error = 0.17 micrograms/mL). We saw no interferences in samples having high concentrations of rheumatoid factors, lipid, bilirubin, or hemoglobin. Cross reactivity with digoxin analogs and steroidal compounds is similar to that observed by RIA.
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
October 1983,
Seminars in thrombosis and hemostasis,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
June 1990,
Transplantation proceedings,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
January 1991,
Journal of clinical laboratory analysis,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
February 1984,
American journal of clinical pathology,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
June 1974,
Clinical chemistry,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
March 1984,
Clinical chemistry,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
January 1986,
Clinical chemistry,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
April 1983,
Clinical chemistry,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
March 1987,
Clinical chemistry,
C C Leflar, and
J W Freytag, and
L M Powell, and
J C Strahan, and
J J Wadsley, and
C A Tyler, and
W K Miller
April 1983,
Clinical chemistry,
