-transparent.png){kind=logo}
We investigated the alterations of phospholipase C activity in the kidney and arterial wall of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Neither DOCA nor salt administration alone affected phospholipase C activity in the kidney and arterial wall. In contrast, when the rats were given both DOCA and salt and developed high blood pressure, the phospholipase C activity became greater in the outer and inner medulla (papilla) while the enzyme activity was reduced significantly in the renal cortex and arterial wall. Such an increase in phospholipase C activity was not observed in the kidney of a genetic rat for spontaneous hypertension. Moreover, the phospholipase A2 activity was also stimulated in the renal medulla of DOCA-salt hypertensive rats. Thus, these data indicate that DOCA-salt hypertension is associated with an increase in phospholipase C activity in the renal medulla, which seems primary to the development of DOCA-salt hypertension.
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
September 1996,
Hypertension research : official journal of the Japanese Society of Hypertension,
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
January 1981,
Clinical and experimental pharmacology & physiology,
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
January 1980,
Clinical and experimental hypertension,
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
January 1998,
Brain research bulletin,
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
October 2009,
Regulatory peptides,
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
April 1986,
Journal of hypertension,
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
August 2017,
Scientific reports,
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
January 2008,
American journal of physiology. Regulatory, integrative and comparative physiology,
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
January 1983,
Hypertension (Dallas, Tex. : 1979),
Y Uehara, and
A Numabe, and
S Takada, and
N Hirawa, and
H Matsuoka, and
T Ikeda, and
S Yagi, and
T Sugimoto
September 1988,
Hypertension (Dallas, Tex. : 1979),
