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Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists. 2010
Abdul Rehman, and
Ajay Soni, and
Keshav Naik, and
Sreeji Nair, and
Venkata P Palle, and
Sunanda Dastidar, and
Abhijit Ray, and
M S Alam, and
Mohammad Salman, and
Ian A Cliffe, and
Viswajanani Sattigeri
Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot 20, Sector 18, Gurgaon 122015, Haryana, India. ab_rehman@rediffmail.com
A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
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