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In diabetes mellitus, the retina is exposed to fluctuations in blood glucose concentrations, presumed decreases in oxygen availability and other metabolic disturbances induced by the disease. These metabolic phenomena may play a role in diabetic retinopathy. To understand these processes better, we measured oxygen consumption in vitro in retinas from normal and diabetic rabbits and examined the effect of oxygen and glucose concentration on retinal respiration. Retinal oxygen consumption is decreased in diabetic retinas compared to normal rabbit retinas (0.56 +/- 0.09 ml of oxygen per min per mg dry weight in normal and 0.40 +/- 0.07 ml of oxygen per min per mg dry weight in diabetic retinas). Retinal oxygen consumption is elevated if the oxygen tension is raised above normal in both groups. Glucose concentration did not significantly effect the oxygen consumption of the retina in either group.
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
January 1951,
Acta medica Scandinavica,
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
July 1954,
Acta endocrinologica,
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
May 1976,
Il Farmaco; edizione pratica,
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
May 1991,
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F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
January 1965,
Physiologia bohemoslovenica,
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
October 1966,
Zentralblatt fur Gynakologie,
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
August 1990,
JAMA,
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
January 1980,
Diabetes care,
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
August 1978,
Archivos de farmacologia y toxicologia,
F S Sutherland, and
E Stefansson, and
D L Hatchell, and
H Reiser
May 1959,
Canadian journal of biochemistry and physiology,
