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Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles. 2010

Sen W Kwok, and Joseph R Fotsing, and Rebecca J Fraser, and Valentin O Rodionov, and Valery V Fokin
The Scripps Research Institute, La Jolla, California 92037, USA.

1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

UI MeSH Term Description Entries
D002384 Catalysis The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction. Catalyses
D006878 Hydroxides Inorganic compounds that contain the OH- group.
D014230 Triazoles Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. Triazole
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D028561 Transition Elements Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements. Elements, Transition

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