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Multifactorial analysis of the combined action of a microbial peptidoglycan and doxycycline on the immune response to antigens of the vaccine EV fraction 1 was made. Nomograms or equal level curves characterizing delayed hypersensitivity (DH) and antibody titers in various doses of the peptidoglycan and the antibiotic were plotted by the experimental data with a computer. The peptidoglycan had a pronounced immunomodulatory action on DH and antibody titers. However, the types of regulation of the both responses markedly differed. With multifactor analysis, the range of the values of the operating parameters, i.e. the drug doses and the time of their administration providing the required levels of DH and antibodies under the conditions of the combined therapy were defined.
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
March 1995,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
December 1992,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
May 1985,
Infection and immunity,
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
May 1992,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
July 2014,
Toxicology and applied pharmacology,
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
January 1990,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
January 2004,
The Journal of nutrition,
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
March 1961,
Bollettino della Societa italiana di biologia sperimentale,
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
April 1988,
Biulleten' eksperimental'noi biologii i meditsiny,
A V Nikitin, and
L P Ivanitskaia, and
L E Bodunkova
March 2011,
BMC evolutionary biology,
